诺氟沙星与甲砜霉素治疗卢旺达单纯性淋病的疗效比较
Norfloxacin versus thiamphenicol for treatment of uncomplicated gonorrhea in Rwanda.
作者信息
Bogaerts J, Martinez Tello W, Verbist L, Piot P, Vandepitte J
出版信息
Antimicrob Agents Chemother. 1987 Mar;31(3):434-7. doi: 10.1128/AAC.31.3.434.
Abstract
In an open prospective study, single oral doses of norfloxacin (800 mg) and thiamphenicol (2.5 g) were used to treat, respectively, 122 and 46 consecutive patients with uncomplicated gonorrhea. Neisseria gonorrhoeae was eradicated from 119 (97.5%) patients treated with norfloxacin and from 35 (76.0%) patients treated with thiamphenicol. Norfloxacin treatment failure was not related to drug resistance or to insufficient absorption of the drug. Thiamphenicol failure correlated with low in vitro susceptibility of the infecting strain. In a single oral dose of 800 mg, norfloxacin appeared to be an excellent alternative treatment regimen for uncomplicated gonorrhea in an area with a high prevalence of penicillin-resistant gonococci.
摘要
在一项开放性前瞻性研究中，分别使用单次口服剂量的诺氟沙星（800毫克）和甲砜霉素（2.5克）治疗122例和46例连续的无并发症淋病患者。接受诺氟沙星治疗的119例（97.5%）患者和接受甲砜霉素治疗的35例（76.0%）患者的淋病奈瑟菌被根除。诺氟沙星治疗失败与耐药性或药物吸收不足无关。甲砜霉素治疗失败与感染菌株的体外低敏感性相关。在单次口服800毫克剂量时，在青霉素耐药淋球菌高流行地区，诺氟沙星似乎是治疗无并发症淋病的一种极佳替代治疗方案。
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