Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
J Colloid Interface Sci. 2019 Sep 1;551:39-46. doi: 10.1016/j.jcis.2019.04.096. Epub 2019 May 2.
Novel cubic gel particles (ssCGP) with Glutathione (GSH) triggered drug release features were prepared by crosslinking the cyclodextrin based metal-organic frameworks (CD-MOFs) templets with a newly synthesized biodegradable disulfide bond-bearing linker and removing of the potassium ion in sequence. The morphology and size of ssCGP were investigated by field emission scanning electron microscope (FESEM) and dynamic light scattering. Energy dispersive x-ray spectroscopy (EDX), fourier transform infrared spectroscopy (FT-IR), powder x-ray diffraction (PXRD) and Brunauer-Emmett-Teller (BET) were employed to characterize the structure of ssCGP. ssCGP have regular hexahedron shape with edge length about 200-400 nm. Excellent ability of drug adsorption was achieved by using doxorubicin (DOX) as a model drug. The GSH triggered drug release of ssCGP was observed both in GSH contained solutions and intracellular environments. ssCGP have been demonstrated as a biocompatible porous nanocarrier, particular for intracellular drug delivery.
新型立方凝胶颗粒（ssCGP）具有谷胱甘肽（GSH）触发的药物释放特性，是通过用新合成的可生物降解的二硫键键合连接体交联基于环糊精的金属有机骨架（CD-MOFs）模板，并依次除去钾离子制备的。通过场发射扫描电子显微镜（FESEM）和动态光散射研究了 ssCGP 的形态和尺寸。能量色散 X 射线光谱（EDX）、傅里叶变换红外光谱（FT-IR）、粉末 X 射线衍射（PXRD）和 Brunauer-Emmett-Teller（BET）用于表征 ssCGP 的结构。ssCGP 具有约 200-400nm 的边长的规则六面体形状。以阿霉素（DOX）为模型药物，实现了良好的药物吸附能力。在含有 GSH 的溶液和细胞内环境中均观察到 ssCGP 的 GSH 触发药物释放。ssCGP 已被证明是一种生物相容性多孔纳米载体，特别适用于细胞内药物递送。
