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用于有效细胞内递送抗癌药物6-巯基嘌呤的谷胱甘肽响应性纳米级金属有机框架材料。

Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine.

作者信息

Gong Ming, Yang Jian, Li Yongsheng, Gu Jinlou

机构信息

Shanghai Engineering Research Center of Hierarchical Nanomaterials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

出版信息

Chem Commun (Camb). 2020 Jun 14;56(47):6448-6451. doi: 10.1039/d0cc02872j. Epub 2020 May 12.

DOI:10.1039/d0cc02872j
PMID:32393947
Abstract

A glutathione-triggered drug delivery system (DDS) based on nanoscale metal-organic frameworks (NMOFs) is developed, which features an intracellular redox-responsive release of an anticancer drug. Compared to normal cells, the current NMOF-based DDS has 3-fold higher cytotoxicity to cancer cells, prefiguring its great potential for selective cancer therapy.

摘要

一种基于纳米级金属有机框架（NMOF）的谷胱甘肽触发药物递送系统（DDS）被开发出来，其特点是抗癌药物在细胞内具有氧化还原响应释放功能。与正常细胞相比，当前基于NMOF的DDS对癌细胞的细胞毒性高3倍，预示着其在选择性癌症治疗方面具有巨大潜力。

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引用本文的文献

[1]
Double Hydroxyl Salt as Smart Biocompatible pH-Responsive Carrier for 6-Mercaptopurine.

Cancers (Basel). 2023-11-30

[2]
Mesoporous Silica Modified with Polydopamine and Zinc Ions as a Potential Carrier in the Controlled Release of Mercaptopurine.

Materials (Basel). 2023-6-13

[3]
Tumor Microenvironment-Responsive 6-Mercaptopurine-Releasing Injectable Hydrogel for Colon Cancer Treatment.

Gels. 2023-4-10

[4]
Cellular Uptake and Transport Mechanism of 6-Mercaptopurine Nanomedicines for Enhanced Oral Bioavailability.

Int J Nanomedicine. 2023

[5]
Metal-Organic Frameworks and Their Composites Towards Biomedical Applications.

Front Mol Biosci. 2021-12-21

[6]
Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms.

Nanomaterials (Basel). 2021-3-16

[7]
Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment.

Int J Mol Sci. 2020-9-2

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