Signalling Programme, Babraham Institute, Babraham, Cambridge, UK
J Cell Biol. 2019 Jun 3;218(6):1767-1768. doi: 10.1083/jcb.201904159. Epub 2019 May 10.
Expansion of the autophagosomal membrane requires a mechanism to supply lipids while excluding most membrane proteins. In this issue, Valverde et al. (2019. https://doi.org/10.1083/jcb.201811139) identify ATG2, a member of the autophagy-related protein family, as a lipid transfer protein and provide important novel insights on how autophagosomes grow.
扩张自噬体膜需要一种机制来提供脂质,同时排除大多数膜蛋白。在本期中,Valverde 等人(2019 年,https://doi.org/10.1083/jcb.201811139)将自噬相关蛋白家族的成员 ATG2 鉴定为一种脂质转移蛋白,并提供了关于自噬体如何生长的重要新见解。