自噬体形成：在 ER 处切断戈尔迪之结。
Autophagosome Formation: Cutting the Gordian Knot at the ER.
机构信息
Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA.
Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA.
出版信息
Curr Biol. 2018 Apr 23;28(8):R347-R349. doi: 10.1016/j.cub.2018.03.015.
Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime suspect. This concept has now been reinforced by recent advances uncovering roles of several ER membrane proteins in autophagosome formation.
自噬体的生物发生及其隔离膜的起源一直是一个长期未解决的问题，内质网及其与其他细胞器的膜接触点仍然是主要的嫌疑对象。最近的研究进展揭示了几种内质网膜蛋白在自噬体形成中的作用，进一步证实了这一概念。
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