SNAre 捕获一个 ARP 需要一个 LIR。
SNAREing an ARP requires a LIR.
机构信息
Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, England, UK
出版信息
J Cell Biol. 2018 Mar 5;217(3):803-805. doi: 10.1083/jcb.201801104. Epub 2018 Feb 15.
The fusion of autophagosomes with lysosomes is an obligatory step in the self-eating process of autophagy. In this issue, Kumar et al. (2018. https://doi.org/10.1083/jcb.201708039) identify a protein complex, the autophagosome recognition particle (ARP), that chaperones a key SNARE, syntaxin 17, to the autophagosome membrane. Intriguingly, this protein complex coordinates both delivery and membrane insertion as a prelude to fusion.
自噬体与溶酶体的融合是自噬过程中自我吞噬的必需步骤。在本期中，Kumar 等人（2018. https://doi.org/10.1083/jcb.201708039）确定了一个蛋白质复合物，即自噬体识别颗粒（ARP），该复合物可以将关键的 SNARE 蛋白突触融合蛋白 17 引导至自噬体膜上。有趣的是，该蛋白复合物在融合之前协调了递呈和膜插入。
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