Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping St., Luzhou, 646000, Sichuan, People's Republic of China.
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People's Republic of China.
Mol Imaging Biol. 2020 Feb;22(1):22-32. doi: 10.1007/s11307-019-01366-x.
Imaging diagnosis of infection and inflammation has been challenging for many years. Infection imaging agents commonly used in nuclear medicine, such as [Ga]citrate, 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG), and radionuclide-labeled leukocytes, have their own shortcomings. Identification of a tracer with considerable economic benefit, high specificity, and low radiation dose has become clinically urgent. In the twenty-first century, with the increasing availability of positron emission tomography (PET) devices and the commercialization of Ge-68/Ga-68 generators, the study of [Ga]citrate applications for infection and inflammation has increased and shown good potential. In this report, the research progress that supports [Ga]citrate PET's applications various infectious diseases and inflammation is reviewed.
多年来，感染和炎症的影像学诊断一直具有挑战性。核医学中常用的感染成像剂，如[Ga]柠檬酸盐、2-脱氧-2-[F]氟代-D-葡萄糖([F]FDG)和放射性核素标记的白细胞，都有其自身的缺点。寻找一种具有显著经济效益、高特异性和低辐射剂量的示踪剂已成为临床急需解决的问题。在 21 世纪，随着正电子发射断层扫描（PET）设备的日益普及和锗-68/镓-68 发生器的商业化，[Ga]柠檬酸盐在感染和炎症中的应用研究不断增加，并显示出良好的应用潜力。本报告综述了支持[Ga]柠檬酸盐 PET 在各种感染性疾病和炎症中的应用的研究进展。
