Lawal Ismaheel, Zeevaart JanRijn, Ebenhan Thomas, Ankrah Alfred, Vorster Mariza, Kruger Hendrik G, Govender Thavendran, Sathekge Mike
Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa.
Radiochemistry, South African Nuclear Energy Corporation SOC Ltd. (Necsa), Pelindaba, Pretoria, South Africa.
J Nucl Med. 2017 Nov;58(11):1727-1732. doi: 10.2967/jnumed.117.191635. Epub 2017 Aug 17.
Metabolic imaging has come to occupy a prominent place in the diagnosis and management of microbial infection. Molecular probes available for infection imaging have undergone a rapid evolution starting with nonspecific agents that accumulate similarly in infection, sterile inflammation, and neoplastic tissue and then extending to more targeted probes that seek to identify specific microbial species. This focus review describes the metabolic and molecular imaging techniques currently available for clinical use in infection imaging and those that have demonstrated promising results in preclinical studies with the potential for clinical applications.
代谢成像在微生物感染的诊断和管理中已占据显著地位。用于感染成像的分子探针经历了快速发展，从在感染、无菌性炎症和肿瘤组织中类似蓄积的非特异性试剂开始，然后扩展到旨在识别特定微生物种类的更具靶向性的探针。本重点综述描述了目前可用于感染成像临床应用的代谢和分子成像技术，以及那些在临床前研究中已显示出有前景的结果且具有临床应用潜力的技术。
