Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Acta Psychiatr Scand. 2017 Sep;136(3):259-268. doi: 10.1111/acps.12758. Epub 2017 May 26.
To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.
Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.
There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men.
High TC levels may be associated with an increased risk of suicide in women.
利用随访时间长的大型一般人群队列研究，探讨血清总胆固醇（TC）与自杀之间的关联。
分析纳入了 1990 年至 2012 年期间日本公共卫生中心前瞻性研究中的 16341 名男性和 28905 名 40-69 岁的女性。TC 水平按照临床指南定义：低（<4.66mmol/l [180mg/dl]）、正常（4.66-5.70mmol/l [180-220mg/dl]）和高（≥5.70mmol/l [220mg/dl]）。使用 Cox 比例风险回归模型根据 TC 水平确定自杀的危险比（HR）和置信区间（CI）。男性的平均随访时间为 19 年，女性为 20 年。
随访期间共发生 185 例自杀（男性：107 例；女性：78 例）。与 TC 正常的女性相比，TC 高的女性自杀风险显著增加（HR=1.90，95%CI，1.13-3.19）。低密度脂蛋白（HR=1.11，95%CI，1.02-1.21）和非高密度脂蛋白胆固醇（HR=1.09，95%CI，1.01-1.18）的微量递增（0.26mmol/l [10mg/dl]）也与女性自杀风险增加相关。在男性中，TC 水平或脂质分数与自杀之间无关联。
高 TC 水平可能与女性自杀风险增加有关。
