Faculté de Médecine Dentaire, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada.
Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151, Richmond St., Kresge Building, Room K214, London, Ontario, N6A 5C1, Canada.
Syst Rev. 2019 May 10;8(1):114. doi: 10.1186/s13643-019-1031-7.
Despite a considerable amount of epidemiological research for identification of risk factors involved in the development of colorectal cancer, the current understanding of the etiology of this disease remains rather poor. Accumulating evidence suggests a potentially important role of infection with Fusobacterium nucleatum in the colon in colorectal carcinogenesis. The objective of this systematic review is to synthesize the epidemiological evidence on the association between infection with Fusobacterium nucleatum in the colon and colorectal cancer.
This systematic review will include observational studies (cohort, case-control, cross-sectional) in humans in which the role of Fusobacterium nucleatum in the etiology of colorectal cancer was investigated. MEDLINE, EMBASE, Web of Science, and Cochrane Database of Systematic Reviews will be searched using a comprehensive search strategy and manual screening of references. Two reviewers will independently identify eligible studies and extract the data from the included studies. The quality of studies will be assessed by using the Newcastle-Ottawa scale. Random-effects models will be used to estimate pooled measures of association (where feasible). Meta-regression and subgroup analyses will be conducted to explore the potential sources of heterogeneity. The Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement will be followed for reporting.
Deepening knowledge regarding the etiology of colorectal cancer and the potential implications of Fusobacterium nucleatum in this disease is instrumental for prevention, diagnosis, and treatment of this often-fatal disease. This review will produce summarized current evidence on this topic.
This systematic review protocol has been registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 10 July 2018 (registration number CRD42018095866).
尽管已经进行了大量的流行病学研究来确定与结直肠癌发展相关的危险因素，但目前对这种疾病的病因学认识仍然相当有限。越来越多的证据表明，梭状芽胞杆菌（Fusobacterium nucleatum）在结肠中的感染可能在结直肠癌的发生中发挥重要作用。本系统综述的目的是综合关于结肠中梭状芽胞杆菌感染与结直肠癌之间关联的流行病学证据。
本系统综述将包括在人类中进行的观察性研究（队列研究、病例对照研究、横断面研究），其中研究了梭状芽胞杆菌在结直肠癌病因学中的作用。将使用全面的检索策略和手动筛选参考文献对 MEDLINE、EMBASE、Web of Science 和 Cochrane 系统评价数据库进行检索。两名审查员将独立确定合格的研究，并从纳入的研究中提取数据。将使用纽卡斯尔-渥太华量表评估研究的质量。如果可行，将使用随机效应模型估计汇总关联度量。将进行荟萃回归和亚组分析，以探索潜在的异质性来源。将遵循观察性研究的荟萃分析（MOOSE）指南和系统评价和荟萃分析的首选报告项目（PRISMA）声明进行报告。
加深对结直肠癌病因学的认识以及梭状芽胞杆菌在这种疾病中的潜在作用，对于预防、诊断和治疗这种常见的致命疾病至关重要。本综述将总结该主题的当前证据。
本系统评价方案已于 2018 年 7 月 10 日在国际前瞻性系统评价注册库（PROSPERO）中进行了注册（登记号 CRD42018095866）。
