具核梭杆菌与结直肠癌的相关性：系统评价和荟萃分析。
The association between Fusobacterium nucleatum and cancer colorectal: A systematic review and meta-analysis.
机构信息
Departamento de Microbiología, Universidad de Granada-Instituto de Investigación BioSanitaria-ibs-Granada, Granada, Spain.
Departamento de Bioestadística de FIBAO, Hospital Universitario Virgen de las Nieves-Instituto de Investigación BioSanitaria-ibs-Granada, Granada, Spain.
出版信息
Enferm Infecc Microbiol Clin (Engl Ed). 2022 May;40(5):224-234. doi: 10.1016/j.eimce.2022.02.007. Epub 2022 Mar 4.
INTRODUCTION
The etiological factors of colorectal cancer (CRC) are not precisely known, although genetic and environmental factors have been implicated. A possible association with Fusobacterium nucleatum may provide opportunities for an early diagnosis.
OBJECTIVE
To review studies that address the association between F. nucleatum and CRC.
METHODS
The MEDLINE PubMed database was searched using the terms «colorectal cancer» and "Fusobacterium nucleatum", retrieving publications published up to January 1 2020. Stata software was used for a meta-analysis.
RESULTS
The systematic review included 57 articles. Meta-analysis results indicated a more frequent presence of F. nucleatum in CRC tumour tissue samples in comparison to control samples of healthy tissue, with an odds ratio of 4.558 (95% CI: 3.312-6.272), and in comparison, to control samples of colorectal adenomas, with an odds ratio of 3.244 (95 % CI: 2.359-4.462).
CONCLUSION
There is a more frequent resence of F. nucleatum in the CRC. However, further studies are needed to verify this relationship.
简介
结直肠癌（CRC）的病因尚不清楚，尽管遗传和环境因素与之相关。与具核梭杆菌可能存在关联，为早期诊断提供了机会。
目的
综述与具核梭杆菌和 CRC 相关的研究。
方法
使用“结直肠癌”和“具核梭杆菌”这两个术语，在 MEDLINE PubMed 数据库中进行检索，检索截至 2020 年 1 月 1 日的出版物。使用 Stata 软件进行荟萃分析。
结果
系统综述共纳入 57 篇文章。荟萃分析结果表明，CRC 肿瘤组织样本中具核梭杆菌的存在频率明显高于健康组织对照样本，优势比为 4.558（95%CI：3.312-6.272），与结直肠腺瘤对照样本相比，优势比为 3.244（95%CI：2.359-4.462）。
结论
CRC 中具核梭杆菌的存在更为频繁。但是，仍需要进一步的研究来验证这种相关性。
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