内分泌干扰物对跨代女性生殖的表观遗传影响†。
The epigenetic impacts of endocrine disruptors on female reproduction across generations†.
机构信息
Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Illinois, USA.
出版信息
Biol Reprod. 2019 Sep 1;101(3):635-644. doi: 10.1093/biolre/ioz081.
Abstract
Humans and animals are repeatedly exposed to endocrine disruptors, many of which are ubiquitous in the environment. Endocrine disruptors interfere with hormone action; thus, causing non-monotonic dose responses that are atypical of standard toxicant exposures. The female reproductive system is particularly susceptible to the effects of endocrine disruptors. Likewise, exposures to endocrine disruptors during developmental periods are particularly concerning because programming during development can be adversely impacted by hormone level changes. Subsequently, developing reproductive tissues can be predisposed to diseases in adulthood and these diseases can be passed down to future generations. The mechanisms of action by which endocrine disruptors cause disease transmission to future generations are thought to include epigenetic modifications. This review highlights the effects of endocrine disruptors on the female reproductive system, with an emphasis on the multi- and transgenerational epigenetic effects of these exposures.
摘要
人类和动物反复暴露于内分泌干扰物中，其中许多物质在环境中普遍存在。内分泌干扰物会干扰激素的作用；因此，导致非单调剂量反应，这是非典型的标准毒物暴露。女性生殖系统特别容易受到内分泌干扰物的影响。同样，在发育期间暴露于内分泌干扰物特别令人担忧，因为在发育过程中的编程可能会受到激素水平变化的不利影响。随后，发育中的生殖组织可能容易患上成年期疾病，这些疾病可以遗传给后代。据认为，内分泌干扰物将疾病传播给后代的作用机制包括表观遗传修饰。这篇综述强调了内分泌干扰物对女性生殖系统的影响，重点介绍了这些暴露的多代和跨代表观遗传效应。
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