College of Chemistry and Chemical Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, 266071 Qingdao, China; College of Chemistry, Jilin University, 130012 Changchun, China.
College of Chemistry and Chemical Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, 266071 Qingdao, China.
Ultrason Sonochem. 2019 Oct;57:223-232. doi: 10.1016/j.ultsonch.2019.04.037. Epub 2019 Apr 27.
The smart biocompatible carriers have an advantage in the high-efficiency delivery and stimuli-responsive release of drugs. This study describes two model magnetic microcapsules (MMC) fabricated by sonicating the hydrophobic drug-loaded oil phase in an albumin aqueous solution, where magnetic nanoparticles are either encapsulated into the core or embedded onto the albumin shell. The as-prepared MMC with magnetic shell (MS) or with magnetic core (MC) shows an appropriate dispersibility with a well-defined spherical morphology in water, an excellent magnetism-mediated shifting ability for targeted drug delivery, and a good biocompatibility for high-level cell viability. Moreover, both the two microcapsules also show a high efficiency to trap the hydrophobic drugs, where the embedding ratios are 87.41% for MMC-MS and 95.31% for MMC-MC, respectively. Meanwhile in current study, the release kinetics and mechanism reveal that the sulfhydryl-crosslinked shell structure endows the MMC with a redox-responsive behavior to release the contents for controlled drug release, and the release rate or the release amount can be adjusted by changing the dosage of reducing agent. Therefore, the MMC have great potential as a smart carrier of hydrophobic drugs for enhancing the therapeutic efficiency.
智能生物相容载体在高效传递和刺激响应释放药物方面具有优势。本研究描述了通过超声处理疏水性载药油相在白蛋白水溶液中制备的两种模型磁性微胶囊（MMC），其中磁性纳米颗粒被包裹在核内或嵌入在白蛋白壳内。所制备的具有磁性壳（MS）或具有磁性核（MC）的 MMC 在水中具有适当的分散性和良好定义的球形形态，具有优异的磁介导靶向药物传递能力，以及高水平细胞活力的良好生物相容性。此外，两种微胶囊都能有效地捕获疏水性药物，其中 MMC-MS 的包埋率为 87.41%，MMC-MC 的包埋率为 95.31%。同时，在本研究中，释放动力学和机制表明，巯基交联壳结构使 MMC 具有氧化还原响应行为，以释放内容物进行控制药物释放，并且可以通过改变还原剂的用量来调节释放速率或释放量。因此，MMC 作为疏水性药物的智能载体具有很大的潜力，可提高治疗效率。
