College of Chemistry, Jilin University, Changchun, Jilin 130012, PR China.
College of Electronic Science and Engineering, Jilin University, Changchun, Jilin 130012, PR China.
Ultrason Sonochem. 2017 May;36:437-445. doi: 10.1016/j.ultsonch.2016.12.027. Epub 2016 Dec 21.
In this study, the biocompatible redox and pH dual-responsive magnetic graphene oxide microcapsules (MGOMCs) were prepared by a simple sonochemical method. The disulfide bonds cross-linked the wall of MGOMCs were formed from the hydrosulfuryl on the surface of thiolated graphene oxide, which was synthesized by functionalizing graphene oxide with cysteine, showed an excellent redox-responsive property to control drugs release. Moreover, oleic acid modified FeO nanoparticles were encapsulated into the microcapsules successfully with the hydrophobic drugs dispersed in the hydroxy silicone oil. The MGOMCs possess distinguished magnetic property and pH-responsive ability. Besides, the microcapsules could be engulfed by Hela cells successfully due to the appropriate size and flexible shell. The MGOMCs could be a good carrier for hydrophobic drugs, especially the anticancer drugs.
在这项研究中，通过简单的超声化学方法制备了具有生物相容性的氧化石墨烯微胶囊（MGOMCs）。MGOMCs 壁上的二硫键是由巯基化氧化石墨烯表面的氢硫基形成的，巯基化氧化石墨烯是通过半胱氨酸功能化氧化石墨烯合成的，具有优异的氧化还原响应性，可控制药物释放。此外，成功地将油酸修饰的 FeO 纳米粒子包封到微胶囊中，疏水性药物分散在羟基硅油中。MGOMCs 具有独特的磁响应性和 pH 响应性。此外，由于合适的尺寸和灵活的外壳，微胶囊可以被 Hela 细胞成功吞噬。MGOMCs 可以作为疏水性药物，特别是抗癌药物的良好载体。
