通过超声化学法制备叶酸修饰的还原响应性淀粉基微胶囊用于靶向药物传递。
Fabrication of folic acid decorated reductive-responsive starch-based microcapsules for targeted drug delivery via sonochemical method.
机构信息
College of Chemistry, Jilin University, Changchun 130012, China.
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
出版信息
Carbohydr Polym. 2018 Nov 15;200:508-515. doi: 10.1016/j.carbpol.2018.08.036. Epub 2018 Aug 10.
In this present study, original, biodegradable, biocompatible, non-immunogenic and non-poisonous folic acid (FA) decorated reductive-responsive starch-based microcapsules (FA-RSMCs) were designed and fabricated via the sonochemical method for targeted delivery and controlled release of hydrophobic drugs. A green hydrophobic fluorescent dye, Coumarin 6 (C6), was encapsulated into the FA-RSMCs as a substitute of hydrophobic drugs. The as-synthesized C6-loaded FA-RSMCs were characterized by DLS, SEM and TEM. The results indicated that the obtained C6-loaded FA-RSMCs had an appropriate size range and could enter into the bloodstream with their splendid stability. Moreover, C6-loaded FA-RSMCs showed a high selectivity to Hela cells, and a brilliant targeted drugs delivery and reductive-responsive release ability for hydrophobic drugs, particularly for hydrophobic anti-cancer drugs.
在本研究中，通过超声化学方法设计并制备了原始的、可生物降解的、生物相容的、非免疫原性和无毒的叶酸（FA）修饰的还原响应性淀粉基微胶囊（FA-RSMCs），用于疏水性药物的靶向递送和控制释放。一种绿色疏水性荧光染料香豆素 6（C6）被包封到 FA-RSMCs 中作为疏水性药物的替代品。所合成的负载 C6 的 FA-RSMCs 通过 DLS、SEM 和 TEM 进行了表征。结果表明，所得负载 C6 的 FA-RSMCs 具有合适的粒径范围，并具有出色的稳定性，可以进入血液循环。此外，负载 C6 的 FA-RSMCs 对 Hela 细胞表现出高选择性，并且具有出色的靶向药物递送和还原响应性释放疏水性药物的能力，特别是疏水性抗癌药物。
Zotero 插件