Dai Xiayun, Deng Qifei, Guo Dongmei, Ni Lei, Li Jichao, Chen Zhenlong, Zhang Ling, Xu Tian, Song Weili, Luo Yongbin, Hu Ling, Hu Caiying, Yi Guilin, Pan Zhiwei
Medical Department, Wuhan Prevention and Treatment Center for Occupational Diseases, Wuhan, China.
Faculty of Preventive Medicine, Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, China.
BMJ Open. 2019 May 10;9(5):e022542. doi: 10.1136/bmjopen-2018-022542.
Serum uric acid (SUA) is both a strong antioxidant and one of the key risk factors of cardiovascular diseases (CVDs). We aimed to investigate the associations of urinary metal profile with SUA in traffic policemen in Wuhan, China.
A cross-sectional study was carried out in traffic policemen.
A seriously polluted Chinese city.
A total of 186 traffic policemen were recruited in this study. About 56 of them worked in the logistics department and the other 130 maintained traffic order or dealt with traffic accidents on the roads. All these subjects had worked as a policeman for at least 1 year.
SUA.
The significantly negative association of lead with SUA was consistent between single-metal and multiple-metal models (p=0.004 and p=0.020, respectively). Vanadium, chromium and tin were reversely associated with SUA levels in the single-metal models after false discovery rate (FDR) adjustment (all < 0.05). One IQR increase in vanadium, chromium, tin and lead was associated with 26.9 µmol/L (95% CI -44.6 to -9.2; p=0.003), 27.4 µmol/L (95% CI -46.1 to -8.8; p=0.004), 11.2 µmol/L (95% CI -18.9 to -3.4; p=0.005) and 16.4 µmol/L (95% CI -27.6 to -5.2; p=0.004) decrease in SUA, respectively. Significant interaction between smoking and vanadium on decreased SUV was found (p = 0.007 and p = 0.028).
Urinary vanadium, chromium, tin and lead were negatively associated with SUA. Vanadium and cigarette smoking jointly affected SUA levels. Further studies are needed to replicate these findings and to investigate the potential mechanisms.
血清尿酸（SUA）既是一种强大的抗氧化剂，也是心血管疾病（CVDs）的关键危险因素之一。我们旨在调查中国武汉交警尿金属谱与SUA之间的关联。
对交警进行了一项横断面研究。
中国一个污染严重的城市。
本研究共招募了186名交警。其中约56人在后勤部门工作，另外130人负责维持交通秩序或处理道路交通事故。所有这些受试者担任警察至少1年。
SUA。
在单金属模型和多金属模型中，铅与SUA之间显著的负相关均一致（分别为p = 0.004和p = 0.020）。在错误发现率（FDR）调整后，单金属模型中钒、铬和锡与SUA水平呈负相关（均<0.05）。钒、铬、锡和铅每增加一个四分位数间距分别与SUA降低26.9 μmol/L（95%CI -44.6至-9.2；p = 0.003）、27.4 μmol/L（95%CI -46.1至-8.8；p = 0.004）、11.2 μmol/L（95%CI -18.9至-3.4；p = 0.005）和16.4 μmol/L（95%CI -27.6至-5.2；p = 0.004）有关。发现吸烟与钒对降低SUA有显著的交互作用（p = 0.007和p = 用28）。
尿钒、铬、锡和铅与SUA呈负相关。钒和吸烟共同影响SUA水平。需要进一步研究来重复这些发现并调查潜在机制。
