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钇-90放射性栓塞剂量学:介入放射科医生的概念

Y90 Radioembolization Dosimetry: Concepts for the Interventional Radiologist.

作者信息

Toskich Beau Bosko, Liu David M

机构信息

Mayo Clinic Florida, Jacksonville, FL.

University of British Columbia, Vancouver, BC, Canada.

出版信息

Tech Vasc Interv Radiol. 2019 Jun;22(2):100-111. doi: 10.1053/j.tvir.2019.02.011. Epub 2019 Feb 27.

Abstract

Transarterial radioembolization (TARE) with beta particle emitting microspheres via Yttrium-90 decay has become a fundamental component of the contemporary Interventional Oncology practice. TARE continues to advance as a result of increased utilization, clinical study, technological improvements, and evolving applications. To maximize TARE safety and efficacy, a core understanding of dosimetry is essential. The intent of this overview is to provide the reader with a general survey of radiation physics and biology, device differentiation, patient selection, anatomic assessment, activity administration models, and procedural techniques involved with TARE dosimetry.

摘要

通过钇 - 90衰变产生β粒子的微球进行经动脉放射性栓塞(TARE)已成为当代介入肿瘤学实践的基本组成部分。由于使用增加、临床研究、技术改进和应用不断发展,TARE仍在不断进步。为了使TARE的安全性和有效性最大化,对剂量测定的核心理解至关重要。本概述的目的是为读者提供有关TARE剂量测定所涉及的辐射物理学和生物学、设备差异、患者选择、解剖评估、活度给药模型及操作技术的全面概述。

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