Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Poland.
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Poland.
Pancreatology. 2019 Jun;19(4):481-487. doi: 10.1016/j.pan.2019.04.010. Epub 2019 May 3.
Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that can lead to local and systemic complications. Repeated attacks of AP can lead to chronic pancreatitis, which markedly increases the probability of developing pancreatic cancer. Although many researchers have attempted to identify the pathogenesis involved in the initiation and aggravation of AP, the disease is still not fully understood, and effective treatment is limited to supportive therapy.
We aim to summarize available literature focused on phytochemicals (berberine, chlorogenic acid, curcumin, emblica officinalis, ellagic acid, cinnamtannin B-1, resveratrol, piperine and lycopene) and discuss their effectiveness and therapeutic value for improving AP.
This study is based on pertinent papers that were retrieved by a selective search using relevant keywords in PubMed and ScienceDirect databases.
Many phytochemicals hold potential in improving AP symptoms and may be a valuable and effective addition to standard treatment of AP. It has already been proven that the crucial factor for reducing the severity of AP is stimulation of apoptosis along with/or inhibition of necrosis. Supplementation of phytochemicals, which target the balance between apoptosis and necrosis can be recommended in ongoing clinical studies.
急性胰腺炎（AP）是一种胰腺炎症性疾病，可导致局部和全身并发症。AP 的反复发作可导致慢性胰腺炎，显著增加胰腺癌的发病概率。尽管许多研究人员试图确定 AP 发病和加重的发病机制，但该疾病仍未被完全了解，有效的治疗方法仅限于支持性治疗。
我们旨在总结现有的关于植物化学物质（小檗碱、绿原酸、姜黄素、余甘子、鞣花酸、肉桂单宁 B-1、白藜芦醇、胡椒碱和番茄红素）的文献，并讨论它们在改善 AP 方面的有效性和治疗价值。
本研究基于使用 PubMed 和 ScienceDirect 数据库中相关关键词进行选择性搜索检索到的相关论文。
许多植物化学物质在改善 AP 症状方面具有潜力，可能是 AP 标准治疗的有价值且有效的补充。已经证明，减轻 AP 严重程度的关键因素是刺激细胞凋亡，同时/或抑制细胞坏死。在正在进行的临床研究中，可以推荐补充以凋亡和坏死平衡为靶向的植物化学物质。
