School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
J Pharm Pharmacol. 2020 Jun;72(6):761-775. doi: 10.1111/jphp.13229. Epub 2020 Feb 3.
Acute pancreatitis (AP) is an inimical disorder associated with overall mortality rates between 10-15%. It is a disorder of the exocrine pancreas which is characterized by local and systemic inflammatory responses primarily driven by oxidative stress and death of pancreatic acinar cells. The severity of AP ranges from mild pancreatic edema with complete recuperative possibilities to serious systemic inflammatory response resulting in peripancreatic/pancreatic necrosis, multiple organ failure, and death.
We have retrieved the potential alternative approaches that are developed lately for efficacious treatment of AP from the currently available literature and recently reported experimental studies. This review summarizes the need for alternative approaches and combinatorial treatment strategies to deal with AP based on literature search using specific key words in PubMed and ScienceDirect databases.
Since AP results from perturbations of multiple signaling pathways, the so called "monotargeted smart drugs" of the past decade is highly unlikely to be effective. Also, the conventional treatment approaches were mainly involved in providing palliative care instead of curing the disease. Hence, many researchers are beginning to focus on developing alternate therapies to treat AP effectively. This review also summarizes the recent trends in the combinatorial approaches available for AP treatment.
急性胰腺炎（AP）是一种严重的疾病，总死亡率在 10-15%之间。它是胰腺外分泌的一种紊乱，其特征是局部和全身炎症反应，主要由氧化应激和胰腺腺泡细胞死亡驱动。AP 的严重程度范围从轻微的胰腺水肿和完全恢复的可能性到严重的全身炎症反应，导致胰周/胰腺坏死、多器官衰竭和死亡。
我们从目前可用的文献和最近报道的实验研究中，检索到了最近开发的针对 AP 有效治疗的潜在替代方法。本综述总结了基于在 PubMed 和 ScienceDirect 数据库中使用特定关键词进行文献检索的需要，基于替代方法和联合治疗策略来应对 AP。
由于 AP 是由多种信号通路的紊乱引起的，过去十年所谓的“单靶点智能药物”极不可能有效。此外，传统的治疗方法主要是提供姑息治疗，而不是治愈疾病。因此，许多研究人员开始专注于开发有效的替代疗法来治疗 AP。本综述还总结了 AP 治疗中联合治疗方法的最新趋势。
