Mejía L F, Gil J C, Jaramillo M
Head Cornea Service, School of Medicine, CES University, Medellín, Colombia; Ophthalmology Research Service, School of Medicine, CES University, Medellín, Colombia.
Ophthalmology Research Service, School of Medicine, CES University, Medellín, Colombia.
Arch Soc Esp Oftalmol (Engl Ed). 2019 Jul;94(7):331-336. doi: 10.1016/j.oftal.2019.03.009. Epub 2019 May 10.
To propose the Intense Pulsed Light (IPL) therapy as a helpful supplementary treatment in patients with dry eye disease.
Retrospective cross sectional design. Medical records of patients in whom dry eye disease symptoms were not satisfactorily controlled with medical therapy alone and who underwent additional IPL with at least three sessions completed. Data were analyzed before therapy and 3weeks after its completion to asses improvement. Determination of symptoms, through a visual analog scale; tear film stability, through tear Break Up Time (tBUT); measurement of tear secretion, through Schirmer Test; and ocular surface staining with Van Bijsterveld score were evaluated. SPSS software and nonparametric analysis of repeated measures were used. The study was approved by the ethics committee.
50 eyes from 25 subjects were reviewed. There were 9 males (36%) and 16 females (64%), with a median age of 59years (IQR 52-64). The median of the symptoms scale was 8 (IQR 8-9) and 3 (IQR 2-4) before and after the therapy respectively (P<.05). The median of BUT was 4 (IQR 3-5) and 10 (IQR 8-11), Schirmer test was 13 (IQR 12-15) and 15 (IQR 13-20), and Van Bijsterveld score was 3 (RIC 3-4) and 2 (IQR 2-3) before and after the therapy respectively (P<.05, for all measurements).
IPL treatment has excellent results regarding both: dry eye disease symptoms improvement and in office objective tests such as tBUT, Schirmer test and Van Bijsterveld score; IPL could be considered as an effective adjunct for dry eye disease.
提出强脉冲光（IPL）疗法作为干眼症患者一种有益的辅助治疗方法。
采用回顾性横断面设计。选取仅接受药物治疗但干眼症症状控制不佳且接受至少三次IPL治疗的患者的病历。在治疗前及治疗完成3周后分析数据以评估改善情况。通过视觉模拟量表测定症状；通过泪膜破裂时间（tBUT）测定泪膜稳定性；通过泪液分泌试验测量泪液分泌；并采用范·比斯特维尔德评分评估眼表染色情况。使用SPSS软件及重复测量的非参数分析方法。该研究经伦理委员会批准。
对25名受试者的50只眼睛进行了评估。其中男性9名（36%），女性16名（64%），中位年龄为59岁（四分位间距52 - 64岁）。治疗前症状量表的中位数为8（四分位间距8 - 9），治疗后为3（四分位间距2 - 4）（P <.05）。治疗前tBUT的中位数为4（四分位间距3 - 5），治疗后为10（四分位间距8 - 11）；泪液分泌试验治疗前为13（四分位间距12 - 15），治疗后为15（四分位间距13 - 20）；范·比斯特维尔德评分治疗前为3（四分位间距3 - 4），治疗后为2（四分位间距2 - 3）（所有测量指标P <.05）。
IPL治疗在改善干眼症症状以及诸如tBUT、泪液分泌试验和范·比斯特维尔德评分等门诊客观检查方面均有出色效果；IPL可被视为干眼症的一种有效辅助治疗方法。
