Kaltschmidt Christian, Banz-Jansen Constanze, Benhidjeb Tahar, Beshay Morris, Förster Christine, Greiner Johannes, Hamelmann Eckard, Jorch Norbert, Mertzlufft Fritz, Pfitzenmaier Jesco, Simon Matthias, Schulte Am Esch Jan, Vordemvenne Thomas, Wähnert Dirk, Weissinger Florian, Wilkens Ludwig, Kaltschmidt Barbara
Department of Cell Biology, Bielefeld University, Universitätsstrasse 25, 33615 Bielefeld, Germany.
Department of Gynecology and Obstetrics, and Perinatal Center, Protestant Hospital of Bethel Foundation, Burgsteig 13, 33617 Bielefeld, Germany.
Cancers (Basel). 2019 May 11;11(5):655. doi: 10.3390/cancers11050655.
Cancer stem cells (CSCs) account for tumor initiation, invasiveness, metastasis, and recurrence in a broad range of human cancers. Although being a key player in cancer development and progression by stimulating proliferation and metastasis and preventing apoptosis, the role of the transcription factor NF-κB in cancer stem cells is still underestimated. In the present review, we will evaluate the role of NF-κB in CSCs of glioblastoma multiforme, ovarian cancer, multiple myeloma, lung cancer, colon cancer, prostate cancer, as well as cancer of the bone. Next to summarizing current knowledge regarding the presence and contribution of CSCs to the respective types of cancer, we will emphasize NF-κB-mediated signaling pathways directly involved in maintaining characteristics of cancer stem cells associated to tumor progression. Here, we will also focus on the status of NF-κB-activity predominantly in CSC populations and the tumor mass. Genetic alterations leading to NF-κB activity in glioblastoma, ependymoma, and multiple myeloma will be discussed.
癌症干细胞（CSCs）在多种人类癌症中导致肿瘤起始、侵袭、转移和复发。转录因子NF-κB虽通过刺激增殖、转移和阻止凋亡在癌症发展和进展中起关键作用，但其在癌症干细胞中的作用仍被低估。在本综述中，我们将评估NF-κB在多形性胶质母细胞瘤、卵巢癌、多发性骨髓瘤、肺癌、结肠癌、前列腺癌以及骨癌的癌症干细胞中的作用。除了总结关于癌症干细胞的存在及其对各类型癌症的贡献的现有知识外，我们将强调直接参与维持与肿瘤进展相关的癌症干细胞特征的NF-κB介导的信号通路。在此，我们还将重点关注主要在癌症干细胞群体和肿瘤块中的NF-κB活性状态。将讨论导致胶质母细胞瘤、室管膜瘤和多发性骨髓瘤中NF-κB活性的基因改变。
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