Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University of Duisburg-Essen, Essen, Germany.
PLoS One. 2019 May 13;14(5):e0216538. doi: 10.1371/journal.pone.0216538. eCollection 2019.
Aortic stiffness is an independent predictor of cardiovascular morbidity and mortality; thus, simple, rapid and preferably automated techniques are indispensable for pursuing a global risk stratification approach. We present an oscillometric technique for determination of the carotid-femoral pulse wave velocity (cfPWV), including the diagnostic accuracy, sensitivity and specificity, with emphasis on the training curve and procedural duration.
In a single-centre crossover study, we evaluated subjects free of known cardiovascular disease (CVD), subjects with CVD and a subgroup of subjects with peripheral artery disease (PAD) in terms of ankle-brachial index (ABI) and PWV measurements determined by oscillometry compared to tonometry. Pearson's correlation analysis was used to assess the relationship of the PWV measurements determined by both methods. Moreover, the time and cost of the examinations were compared.
A total of 176 study subjects underwent assessments to obtain oscillometric and tonometric PWV measurements. The CVD-free subjects (n = 59) were younger (60.4±15.6 vs. 67.5±12.9 years, p = 0.003) than the subjects with CVD (n = 117). The PWV measurements showed significant correlations in CVD-free subjects (r = 0.797, p<0.001), in subjects with CVD (r = 0.817, p<0.001) and in the subgroup of subjects with PAD (r = 0.807, p<0.001). The examination duration was shorter for the oscillometric method than the tonometric method (4.4±0.5 vs. 9.2±0.8 min, p<0.001).
Using a simple and rapid automated oscillometric method, we achieved good diagnostic accuracy for the determination of aortic stiffness through the PWV in both subjects with and without CVD. This method might be helpful in daily practice in terms of saving time and reducing procedural complexity for screening for cardiovascular morbidities and vascular damage in cases of atherosclerosis.
主动脉僵硬是心血管发病率和死亡率的独立预测因子；因此，简单、快速且最好是自动化的技术对于进行全面风险分层方法是不可或缺的。我们提出了一种用于确定颈股脉搏波速度（cfPWV）的振荡测量技术，包括诊断准确性、敏感性和特异性，并重点介绍了训练曲线和程序持续时间。
在一项单中心交叉研究中，我们评估了无已知心血管疾病（CVD）的受试者、有 CVD 的受试者以及外周动脉疾病（PAD）亚组的受试者的踝臂指数（ABI）和通过振荡测量法确定的 PWV 测量值与通过测压法确定的 PWV 测量值进行比较。使用 Pearson 相关分析评估两种方法确定的 PWV 测量值之间的关系。此外，还比较了检查的时间和成本。
共有 176 名研究对象接受了评估，以获得振荡测量法和测压测量法的 PWV 测量值。无 CVD 的受试者（n=59）比有 CVD 的受试者（n=117）更年轻（60.4±15.6 岁 vs. 67.5±12.9 岁，p=0.003）。无 CVD 的受试者（r=0.797，p<0.001）、有 CVD 的受试者（r=0.817，p<0.001）和 PAD 亚组的受试者（r=0.807，p<0.001）中，PWV 测量值之间存在显著相关性。与测压法相比，振荡测量法的检查时间更短（4.4±0.5 分钟 vs. 9.2±0.8 分钟，p<0.001）。
使用简单快速的自动振荡测量法，我们通过 PWV 在有和无 CVD 的受试者中都获得了良好的主动脉僵硬诊断准确性。在日常实践中，这种方法可能有助于节省时间并降低程序复杂性，以筛查心血管疾病和动脉粥样硬化情况下的血管损伤。
