Luo Fei, Ma Chunlei, Wu Jianhui, Li Jian
1 Department of Urology, Tianjin Union Medical Center, Tianjin, China.
2 Department of Urology, Tianjin Fourth Central Hospital, Tianjin, China.
Photobiomodul Photomed Laser Surg. 2019 May;37(5):312-317. doi: 10.1089/photob.2018.4592. Epub 2019 Apr 11.
An elevated neutrophil-to-lymphocyte ratio (NLR) is significantly associated with poor outcomes in many types of malignancies, including bladder cancer. However, the prognostic value of NLR in patients with nonmuscle-invasive bladder cancer (NMIBC) treated with GreenLight photoselective vaporization of bladder tumor (PVBT) has not been well studied. In this study, we aimed to explore the association between NLR and survival outcomes in patients with NMIBC who underwent PVBT. We retrospectively investigated 463 patients with NMIBC who underwent PVBT in Tianjin Union Medical center from January 2012 to January 2017. The patients were divided into two groups based on the NLR value (NLR ≥2.5 and NLR <2.5). Overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were determined using Kaplan-Meier analysis and the log-rank test. Among 463 patients, age, tumor size, tumor focality, tumor grade, or tumor stage in the two groups did not differ significantly. The median follow-up was 40 months (range, 15-60). Thirty-eight patients (8.2%) died of any cause; 24 (5.2%) patients died of bladder cancer. In addition, 88 (19.0%) patients experienced disease recurrence. Elevated NLR was significantly associated with poor OS ( = 7.457, = 0.002), CSS ( = 6.242, = 0.012), and RFS ( = 5.372, = 0.020) in patients with NMIBC who underwent PVBT. Elevated preoperative NLR was significantly associated with poor OS, CSS, and RFS, and it could be considered as an effective and convenient prognostic biomarker for patients with NMIBC who were treated with PVBT.
中性粒细胞与淋巴细胞比值（NLR）升高与包括膀胱癌在内的多种恶性肿瘤的不良预后显著相关。然而，NLR在接受绿激光膀胱肿瘤选择性汽化术（PVBT）治疗的非肌层浸润性膀胱癌（NMIBC）患者中的预后价值尚未得到充分研究。在本研究中，我们旨在探讨接受PVBT的NMIBC患者中NLR与生存结局之间的关联。我们回顾性调查了2012年1月至2017年1月在天津医科大学总医院接受PVBT的463例NMIBC患者。根据NLR值（NLR≥2.5和NLR<2.5）将患者分为两组。采用Kaplan-Meier分析和对数秩检验确定总生存期（OS）、癌症特异性生存期（CSS）和无复发生存期（RFS）。在463例患者中，两组患者的年龄、肿瘤大小、肿瘤灶性、肿瘤分级或肿瘤分期无显著差异。中位随访时间为40个月（范围15 - 60个月）。38例（8.2%）患者因任何原因死亡；24例（5.2%）患者死于膀胱癌。此外，88例（19.0%）患者出现疾病复发。接受PVBT的NMIBC患者中，NLR升高与较差的OS（χ² = 7.457，P = 0.002）、CSS（χ² = 6.242，P = 0.012）和RFS（χ² = 5.372，P = 0.020）显著相关。术前NLR升高与较差的OS、CSS和RFS显著相关，它可被视为接受PVBT治疗的NMIBC患者一种有效且便捷的预后生物标志物。
