Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.
Ultrason Sonochem. 2019 Jul;55:57-66. doi: 10.1016/j.ultsonch.2019.03.010. Epub 2019 Mar 11.
The synthesis of nanoparticles often result in the generation of harmful chemical pollutants. As such, many researchers have focused on developing green processes, which include the biosynthesis. In this research, ZnO nanoparticles were prepared using the leaf extract of whortleberry (Vaccinium arctostaphylos L.) via a simple ultrasonic-assisted method. The morphology, crystal size and structure, surface, thermal, and optical properties of the bio-mediated ZnO sample (ZnO) were analyzed and compared with that produced without incorporating the extract (ZnO). The ZnO samples were evaluated for their antidiabetic, antibacterial, as well as their sono- and photo-catalytic performances. Initially, the samples were intraperitoneal injected to alloxan-diabetic rats to examine their treatment efficiency in terms of effects on fasting blood glucose, insulin, cholesterol, high-density lipoprotein, and total triglyceride levels. The ZnO showed significantly higher efficiency for improving the health status of alloxan-diabetic rats in contrast with other tested treatments, vis. ZnO, insulin, and only leaf extract. In addition, both the ZnO samples were assessed against gram-negative and gram-positive bacteria and through sono- and photo-catalytic processes for removing rhodamine B, respectively. The results of this study indicated that not only the ZnO sample was pollution free, it also exhibited higher potentials for treating diabetic rats, bacterial decontamination, and also oxidative removal of organic compounds under the influences of ultrasound and UV irradiations when compared with ZnO sample.
纳米粒子的合成通常会产生有害的化学污染物。因此，许多研究人员专注于开发绿色工艺，包括生物合成。在这项研究中，通过简单的超声辅助法，使用越橘（Vaccinium arctostaphylos L.）叶提取物制备了 ZnO 纳米粒子。分析和比较了生物介导的 ZnO 样品（ZnO）的形貌、晶体尺寸和结构、表面、热和光学性质与未掺入提取物的 ZnO 的性质。评估了 ZnO 样品的抗糖尿病、抗菌以及声-光催化性能。最初，将样品腹腔注射到四氧嘧啶糖尿病大鼠体内，以检查它们在空腹血糖、胰岛素、胆固醇、高密度脂蛋白和总甘油三酯水平方面对治疗效果的影响。与其他测试的治疗方法（ZnO、胰岛素和仅叶提取物）相比，ZnO 显著提高了改善四氧嘧啶糖尿病大鼠健康状况的效率。此外，还分别通过革兰氏阴性和革兰氏阳性细菌评估了两种 ZnO 样品，并通过声-光催化过程去除罗丹明 B。这项研究的结果表明，与 ZnO 样品相比，不仅 ZnO 样品无污染，而且在超声和紫外辐射的影响下，它还表现出更高的治疗糖尿病大鼠、细菌净化和有机化合物氧化去除的潜力。
