Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, P.O. Box 179, Ardabil, Iran.
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, P.O. Box 179, Ardabil, Iran.
Ultrason Sonochem. 2019 Nov;58:104613. doi: 10.1016/j.ultsonch.2019.104613. Epub 2019 May 28.
The leaf extract of a medicinally important plant, watercress (Nasturtium officinale), was obtained through an ultrasound-facilitated method and utilized for the preparation of ZnO nanoparticles via a joint ultrasound-microwave assisted procedure. The characteristics of the extract enriched nanoparticles (Ext/ZnO) were determined by SEM, TEM, XRD, EDX, BET, FTIR, TGA, and UV-Vis DRS analyses and compared to that of ZnO prepared in the absence of the extract (ZnO). The presence of carbon and carbonaceous bonds, changes in the morphology, size, band gap energy, and weight-decay percentage were a number of differences between ZnO and Ext/ZnO that confirmed the link of extract over nanoparticles. Ext/ZnO, watercress leaf extract, ZnO, and insulin therapies were administrated to treat alloxan-diabetic Wister rats and their healing effectiveness results were compared to one another. The serum levels of the main diabetic indices such as insulin, fasting blood glucose, and lipid profile (total triglyceride, total cholesterol, and high-density lipoprotein cholesterol) were estimated for healthy, diabetic, and the rats rehabilitated with the studied therapeutic agents. The watercress extract-enriched ZnO nanoparticles offered the best performance and suppressed the diabetic status of rats. Moreover, both ZnO samples satisfactory inhibited the activities of Staphylococcus aureus and Escherichia coli bacteria. Based on the results, the application of Nasturtium officinale leaf extract can strongly empower ZnO nanoparticles towards superior antidiabetic and enhanced antibacterial activities.
水芹（ Nasturtium officinale）这种药用植物的叶提取物是通过超声辅助法获得的，并通过联合超声-微波辅助法用于制备 ZnO 纳米粒子。通过 SEM、TEM、XRD、EDX、BET、FTIR、TGA 和 UV-Vis DRS 分析来确定富含提取物的纳米粒子（Ext/ZnO）的特性，并将其与未使用提取物（ZnO）制备的 ZnO 进行比较。存在碳和碳键、形态、尺寸、带隙能和重量衰减百分比的变化是 ZnO 和 Ext/ZnO 之间的一些差异，这些差异证实了提取物与纳米粒子之间的联系。将 Ext/ZnO、水芹叶提取物、ZnO 和胰岛素疗法施用于治疗链脲佐菌素诱导的糖尿病 Wister 大鼠，并将它们的治疗效果进行比较。对健康、糖尿病大鼠和用研究治疗剂康复的大鼠的主要糖尿病指标（胰岛素、空腹血糖和血脂谱（总三酰甘油、总胆固醇和高密度脂蛋白胆固醇）的血清水平进行评估。水芹提取物丰富的 ZnO 纳米粒子表现出最佳的性能，抑制了大鼠的糖尿病状态。此外，两种 ZnO 样品都能满意地抑制金黄色葡萄球菌和大肠杆菌的活性。基于这些结果，应用水芹叶提取物可以有力地增强 ZnO 纳米粒子的抗糖尿病和增强抗菌活性。
