Xu Ru, Su Chen, Cui Longlong, Zhang Kun, Li Jingan
School of Life Science, Zhengzhou University, Zhengzhou 450000, China.
School of Material Science and Engineering & Henan Key Laboratory of Advanced Magnesium Alloy & Key Laboratory of materials processing and mold technology (Ministry of Education), Zhengzhou University, Zhengzhou 450001, China.
Materials (Basel). 2019 May 13;12(9):1570. doi: 10.3390/ma12091570.
Inhibition of residual malignant tumors in patients with colon cancer after operation is one of the difficulties in rehabilitation treatment. At present, using biocompatible materials to remove the copper ion which is the growth dependence of malignant tumors in the lesion site is considered to be the frontier means to solve this problem. In this work, we developed a sodium alginate (SA)/polyethyleneimine (PEI) hydrogel sphere via cross-linking method (SA/SP/SA; SP = SA/PEI) as an oral biomaterial for adsorbing and removing copper ions from colon cancer lesions. The evaluated results showed that the SA/PEI/SA (SPS) hydrogel sphere obtained the largest swelling rate at pH 8.3 which was the acid-base value of colon microenvironment and absorbed more copper ions compared with the SA control. The cell experiment presented that the SPS hydrogel sphere owned better compatibility on normal fibroblasts and promoted higher death of colon cancer cells compared with SA/PEI (SP) and SA control. Our data suggested that the SA/PEI hydrogel sphere had the potentiality as an oral biomaterial for inhibiting colon cancer cells.
抑制结肠癌患者术后残留恶性肿瘤是康复治疗中的难题之一。目前，利用生物相容性材料去除病变部位作为恶性肿瘤生长依赖的铜离子被认为是解决该问题的前沿手段。在本研究中，我们通过交联法制备了海藻酸钠（SA）/聚乙烯亚胺（PEI）水凝胶球（SA/SP/SA；SP = SA/PEI）作为口服生物材料，用于从结肠癌病变部位吸附和去除铜离子。评估结果表明，SA/PEI/SA（SPS）水凝胶球在结肠微环境酸碱值pH 8.3时具有最大溶胀率，且与SA对照组相比能吸附更多铜离子。细胞实验表明，与SA/PEI（SP）和SA对照组相比，SPS水凝胶球对正常成纤维细胞具有更好的相容性，并能促进结肠癌细胞更高的死亡率。我们的数据表明，SA/PEI水凝胶球有潜力作为一种口服生物材料用于抑制结肠癌细胞。
