Yao Hang, Li Jingan, Li Na, Wang Kebing, Li Xin, Wang Jin
Key Laboratory of Advanced Technology for Materials of Chinese Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450000, China.
Polymers (Basel). 2017 Nov 10;9(11):598. doi: 10.3390/polym9110598.
A delay in the endothelialization process represents a bottleneck in the application of a drug-eluting stent (DES) during cardiovascular interventional therapy, which may lead to a high risk of late restenosis. In this study, we used a novel active drug, estradiol, which may contribute to surface endothelialization of a DES, and prepared an estradiol-loaded poly (trimethylene carbonate) film (PTMC-E5) on the surface of the DES material, 316L stainless steel (316L SS), in order to evaluate its function in improving surface endothelialization. All the in vitro and in vivo experiments indicated that the PTMC-E5 film significantly improved surface hemocompatibility and anti-hyperplasia, anti-inflammation and pro-endothelialization properties. This novel drug-delivery system may provide a breakthrough for the surface endothelialization of cardiovascular DES.
内皮化过程的延迟是药物洗脱支架（DES）在心血管介入治疗中应用的一个瓶颈，这可能导致晚期再狭窄的高风险。在本研究中，我们使用了一种新型活性药物雌二醇，它可能有助于DES的表面内皮化，并在DES材料316L不锈钢（316L SS）表面制备了负载雌二醇的聚碳酸三亚甲酯薄膜（PTMC-E5），以评估其在改善表面内皮化方面的功能。所有体外和体内实验均表明，PTMC-E5薄膜显著改善了表面血液相容性以及抗增生、抗炎和促内皮化特性。这种新型药物递送系统可能为心血管DES的表面内皮化提供突破。
