亲本的辅助性T细胞功能导致F1嵌合体。存在一个单独的T细胞亚群，它能够刺激同种异体B细胞，但不能刺激同基因B细胞。
T-helper function of parent leads to F1 chimeras. Presence of a separate T-cell subgroup able to stimulate allogeneic B cells but not syngeneic B cells.
作者信息
Sprent J, von Boehmer H
出版信息
J Exp Med. 1979 Feb 1;149(2):387-97. doi: 10.1084/jem.149.2.387.
Abstract
Parent leads to F1 chimeras were prepared by reconstituting sublethally irradiated H-2 heterozygous mice with marrow cells from one parental strain. Purified parental strain T cells prepared from unprimed chimeras were exposed to sheep erythrocytes in heavily irradiated mice of each of the two parental strains and recovered from thoracic duct lymph of the recipients at either day 1 or day 5 posttransfer. The lymphoborne cells were then tested for their capacity to collaborate in vivo with B cells of the two parental strains. From this approach it was concluded that parent leads to F1 chimera T cells contain two discrete subgroups of T-helper cells, one specific for self H-2 determinants and the other restricted to H-2 determinants of the opposite parental strain. The restrictions mapped to the K-end of the H-2 complex.
摘要
通过用来自一个亲本品系的骨髓细胞重建经亚致死剂量照射的H-2杂合小鼠来制备亲代到F1嵌合体。从未致敏的嵌合体中制备的纯化亲本品系T细胞，在两个亲本品系的每一个经重度照射的小鼠中与绵羊红细胞接触，并在转移后第1天或第5天从受体的胸导管淋巴中回收。然后测试这些淋巴携带细胞在体内与两个亲本品系的B细胞协作的能力。从这个方法得出的结论是，亲代到F1嵌合体T细胞包含两个离散的辅助性T细胞亚群，一个对自身H-2决定簇具有特异性，另一个则受限于相反亲本品系的H-2决定簇。这些限制定位到H-2复合体的K端。
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T-helper function of parent leads to F1 chimeras. Presence of a separate T-cell subgroup able to stimulate allogeneic B cells but not syngeneic B cells.亲本的辅助性T细胞功能导致F1嵌合体。存在一个单独的T细胞亚群，它能够刺激同种异体B细胞，但不能刺激同基因B细胞。
J Exp Med. 1979 Feb 1;149(2):387-97. doi: 10.1084/jem.149.2.387.
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本文引用的文献
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A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
2
Circulating T and B lymphocytes of the mouse. I. Migratory properties.小鼠循环T淋巴细胞和B淋巴细胞。I. 迁移特性。
Cell Immunol. 1973 Apr;7(1):10-39. doi: 10.1016/0008-8749(73)90180-9.
3
Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。II. 来自同种异体供体品系的T淋巴细胞和B淋巴细胞在对半抗原-蛋白质结合物的体液反应中缺乏生理性协同相互作用。
J Exp Med. 1973 Jun 1;137(6):1405-18. doi: 10.1084/jem.137.6.1405.
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Can tolerant allogeneic cells restore nude mice?耐受性异基因细胞能使裸鼠恢复吗？
Cell Immunol. 1975 Dec;20(2):241-6. doi: 10.1016/0008-8749(75)90101-x.
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Allogeneic carrier-specific enhancement of hapten-specific secondary B-cell responses.半抗原特异性二次B细胞应答的同种异体载体特异性增强。
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The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.巨噬细胞在辅助性T细胞生成中的作用。II. 巨噬细胞与T细胞相互作用以通过可溶性抗原诱导辅助性细胞的遗传控制。
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H-2 antigens of the thymus determine lymphocyte specificity.胸腺的H-2抗原决定淋巴细胞特异性。
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Adaptive differentiation of murine lymphocytes. I. Both T and B lymphocytes differentiating in F1 transplanted to parental chimeras manifest preferential cooperative activity for partner lymphocytes derived from the same parental type corresponding to the chimeric host.小鼠淋巴细胞的适应性分化。I. 移植到亲代嵌合体中的F1代中分化的T淋巴细胞和B淋巴细胞，对源自与嵌合宿主相对应的同一亲代类型的伙伴淋巴细胞均表现出优先的协同活性。
J Exp Med. 1978 Sep 1;148(3):727-45. doi: 10.1084/jem.148.3.727.
10
Restricted helper function of F1 leads to parent bone marrow chimeras controlled by K-end of H-2 complex.F1的受限辅助功能导致由H-2复合体的K端控制的亲代骨髓嵌合体。
J Exp Med. 1978 Jun 1;147(6):1838-42. doi: 10.1084/jem.147.6.1838.
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