F1的受限辅助功能导致由H-2复合体的K端控制的亲代骨髓嵌合体。
Restricted helper function of F1 leads to parent bone marrow chimeras controlled by K-end of H-2 complex.
作者信息
Sprent J
出版信息
J Exp Med. 1978 Jun 1;147(6):1838-42. doi: 10.1084/jem.147.6.1838.
Abstract
F1 leads to parent bone marrow chimeras were prepared by transferring F1 hybrid marrow cells into heavily irradiated parental strain mice. When unprimed, donor-derived F1 T cells from the chimeras were activated to sheep erythrocytes (SRC) for 5 days in irradiated normal F1 mice, high IgM and IgG anti-SRC responses were observed with F1 B cells, and with B cells H-2-compatible with the strain in which the T cells were raised from stem cells. Significantly, however, responses with B cells of the opposite parental strain were either absent or very low. The restriction in T-helper function mapped to the K-end of the H-2 complex and could not be attributed to active suppression.
摘要
通过将F1杂种骨髓细胞移植到经大量照射的亲本品系小鼠中制备F1致亲代骨髓嵌合体。当未致敏时，将嵌合体中供体来源的F1 T细胞在经照射的正常F1小鼠中用绵羊红细胞（SRC）激活5天，观察到F1 B细胞以及与T细胞从干细胞发育而来的品系H-2相容的B细胞产生高IgM和IgG抗SRC反应。然而，值得注意的是，来自相反亲本品系的B细胞的反应要么不存在，要么非常低。T辅助功能的限制定位于H-2复合体的K端，且不能归因于主动抑制。
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Restricted helper function of F1 leads to parent bone marrow chimeras controlled by K-end of H-2 complex.F1的受限辅助功能导致由H-2复合体的K端控制的亲代骨髓嵌合体。
J Exp Med. 1978 Jun 1;147(6):1838-42. doi: 10.1084/jem.147.6.1838.
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5
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