Children's Hospital Research Institute of Manitoba, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Centre for Healthcare Innovation, University of Manitoba, Winnipeg, MB, Canada.
Pediatr Res. 2019 Oct;86(4):522-528. doi: 10.1038/s41390-019-0414-8. Epub 2019 May 13.
To determine whether adverse childhood experiences were associated with weight gain and obesity risk in adolescence.
We analyzed data from 6942 adolescents followed between 9 and 13 years of age in the Growing Up in Ireland cohort study. The main exposures were 14 adverse childhood experiences, 4 of which were included in the Adverse Childhood Experience (ACE) study. The primary outcome was incident overweight and obesity at 13 years. Secondary outcomes included prevalent overweight/obesity and weight gain.
More than 75% of the youth experienced an adverse experience and 17% experienced an ACE-specific experience before 9 years. At 13 years, 48% were female and 31.4% were overweight or obese. After adjusting for confounding, exposure to any adverse experience was associated with prevalent overweight/obesity (aOR: 1.56; 1.19-2.05) and incident overweight/obesity (adjusted IRR: 2.15; 95% CI: 1.37-3.39), while exposure to an ACE-specific exposure was associated weight gain (BMI Z score change = 0.202; 95% CI: 0.100-0.303). A significant interaction between income and adverse childhood experiences was observed for both incident overweight/obesity and weight gain (BMI Z change: -0.046; 95% CI: -0.092 to 0.000).
Adverse childhood experiences and low income interact and independently predict obesity risk in early adolescence.
确定儿童期不良经历是否与青少年时期的体重增加和肥胖风险相关。
我们分析了在爱尔兰成长队列研究中，6942 名青少年在 9 至 13 岁期间随访的数据。主要暴露因素是 14 种儿童期不良经历，其中 4 种包含在不良儿童经历（ACE）研究中。主要结局是 13 岁时超重和肥胖的发生率。次要结局包括现患超重/肥胖和体重增加。
超过 75%的青少年经历过不良经历，17%的青少年在 9 岁之前经历过 ACE 特定经历。在 13 岁时，48%是女性，31.4%超重或肥胖。在调整混杂因素后，任何不良经历的暴露与现患超重/肥胖（aOR：1.56；1.19-2.05）和超重/肥胖的发生率（调整后的 IRR：2.15；95%CI：1.37-3.39）相关，而 ACE 特定暴露与体重增加（BMI Z 评分变化 = 0.202；95%CI：0.100-0.303）相关。收入和儿童期不良经历之间存在显著的交互作用，对超重/肥胖的发生率和体重增加均有影响（BMI Z 变化：-0.046；95%CI：-0.092 至 0.000）。
儿童期不良经历和低收入相互作用并独立预测青少年早期的肥胖风险。
