Alberti Adriano, Araujo Coelho David Richer, Vieira Willians Fernando, Moehlecke Iser Betine, Lampert Rose Meiry Fernandez, Traebert Eliane, Silva Bruna Becker da, Oliveira Bruna Hoffmann de, Leão Graziela Marques, Souza Gabriela de, Dallacosta Fabiana Meneghetti, Kades Gabriela, Madeira Kristian, Chupel Matheus Uba, Grossl Fernando Schorr, Souza Renan, Hur Soares Ben, Endrigo Ruppel da Rocha Ricelli, da Silva Sipriano Erica, Fernandes Martins Daniel, Agostinetto Lenita
Department of Biological and Health Sciences Program in Health Sciences, University of Southern Santa Catarina (UNISUL), Palhoça 88132-260, Brazil.
Graduate Program in Environment and Health, University of Planalto Catarinense-UNIPLAC, Lages 88509-900, Brazil.
Biomedicines. 2024 Sep 2;12(9):1994. doi: 10.3390/biomedicines12091994.
Depression affects several aspects of life, including socioeconomic status, relationships, behavior, emotions, and overall health. The etiology of depression is complex and influenced by various factors, with obesity emerging as a significant contributor. This narrative review aims to investigate the factors associated with the development of depression, with a particular focus on the role of obesity. The literature search was conducted on PubMed, Embase, and PsycINFO from May to July 2024. The review highlights the impact of environmental and socioeconomic conditions; lifestyle choices, including physical activity and dietary habits; stress; traumatic experiences; neurotransmitter imbalances; medical and psychological conditions; hormone fluctuations; and epigenetic factors on depression. A key emphasis is placed on the inflammatory processes linked to obesity, which may drive the bidirectional relationship between obesity and depression. The findings suggest that obesity is associated with an increased risk of depression, potentially due to chronic inflammation, neurochemical dysregulation, and the emotional and social challenges related to weight stigma and obesity management. Understanding these interconnected factors is important for developing targeted interventions to address both obesity and depression, leading to improved quality of life for those affected.
抑郁症会影响生活的多个方面，包括社会经济地位、人际关系、行为、情绪和整体健康。抑郁症的病因复杂，受多种因素影响，肥胖已成为一个重要因素。这篇叙述性综述旨在调查与抑郁症发生相关的因素，特别关注肥胖的作用。于2024年5月至7月在PubMed、Embase和PsycINFO上进行了文献检索。该综述强调了环境和社会经济状况、生活方式选择（包括体育活动和饮食习惯）、压力、创伤经历、神经递质失衡、医学和心理状况、激素波动以及表观遗传因素对抑郁症的影响。重点强调了与肥胖相关的炎症过程，这可能推动肥胖与抑郁症之间的双向关系。研究结果表明，肥胖与抑郁症风险增加有关，这可能是由于慢性炎症、神经化学失调以及与体重耻辱感和肥胖管理相关的情感和社会挑战所致。了解这些相互关联的因素对于制定针对性干预措施以解决肥胖和抑郁症问题至关重要，这将改善受影响人群的生活质量。
