X 连锁无丙种球蛋白血症伴围生期人类免疫缺陷病毒暴露 11 周男婴中加速免疫缺陷相关疫苗衍生脊灰病毒 3 型序列进化率。
Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure.
机构信息
Centre for Vaccines and Immunology, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg.
Department of Paediatric Neurology, Neuroscience Institute, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa.
出版信息
Clin Infect Dis. 2020 Jan 1;70(1):132-135. doi: 10.1093/cid/ciz361.
Abstract
Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.
摘要
原发性 B 细胞免疫缺陷是疫苗衍生脊髓灰质炎病毒产生的危险因素。我们报告了一例 X 连锁无丙种球蛋白血症 11 周龄男孩发生与免疫缺陷相关的疫苗衍生脊髓灰质炎病毒 3 型。该病例的独特特征包括发病年龄早、病毒进化速度快，以及患儿围产期感染人类免疫缺陷病毒。
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