Key Laboratory of Biomedical Engineering of Fujian Province University/Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials , Xiamen University , Xiamen 361005 , China.
ACS Appl Mater Interfaces. 2019 Jun 5;11(22):19763-19773. doi: 10.1021/acsami.9b03458. Epub 2019 May 24.
Novel photothermal nanoagents (PTNAs) with excellent photothermal performance, smart-responsive property, and biocompatibility are in urgent need for precise chemo-photothermal cancer therapy. Herein, polynorepinephrine nanoparticles (PNE NPs) with a high photothermal conversion efficiency (η) of 808 nm laser (67%), pH/thermal responsibility, and little to no long-term toxicity were synthesized from an endogenic neurotransmitter norepinephrine. Compared to their analogues, polydopamine NPs, a widely used PTNA, PNE NPs exhibited a higher η value (enhanced 1.63-fold) and better cellular uptake efficiency (enhanced 2.57-fold). After modifying with polyethylene glycol (PEG) and loading with doxorubicin (DOX), PNE-PEG@DOX could realize responsive release of DOX under either a cytolysosome pH microenvironment (pH 5.0) or an 808 nm laser irradiation, resulting in an enhanced chemotherapeutic efficacy of DOX. Besides, in vivo combination therapy leads to nearly complete ablation of tumor tissues, while no significant side effects were found in normal tissues. Hence, this intelligent and biocompatible nanoplatform based on PNE NPs holds great potential in promoting the clinic transformation of precise chemo-photothermal cancer therapy.
新型光热纳米制剂（PTNAs）具有优异的光热性能、智能响应特性和生物相容性，是精准化光热化疗的迫切需求。本文采用内源性神经递质去甲肾上腺素合成了具有高光热转换效率（η）（808nm 激光下 67%）、pH/热响应性和低长期毒性的聚去甲肾上腺素纳米颗粒（PNE NPs）。与广泛应用的光热纳米制剂聚多巴胺纳米颗粒（PDA NPs）相比，PNE NPs 的 η 值更高（增强 1.63 倍），细胞摄取效率更高（增强 2.57 倍）。经聚乙二醇（PEG）修饰并负载阿霉素（DOX）后，PNE-PEG@DOX 可在溶酶体 pH 微环境（pH 5.0）或 808nm 激光照射下实现 DOX 的响应性释放，从而增强 DOX 的化疗效果。此外，体内联合治疗可导致肿瘤组织几乎完全消融，而正常组织未见明显副作用。因此，这种基于 PNE NPs 的智能生物相容性纳米平台在促进精准光热化疗的临床转化方面具有巨大潜力。
