吸烟与性激素改变临床指标的关联——一项对50145名女性的研究。
The association of smoking with clinical indicators of altered sex steroids--a study of 50,145 women.
作者信息
Hartz A J, Kelber S, Borkowf H, Wild R, Gillis B L, Rimm A A
出版信息
Public Health Rep. 1987 May-Jun;102(3):254-9.
This study was designed to test the association of smoking with four clinically apparent conditions that may be related to altered sex steroids: natural and induced menopause, infertility, oligomenorrhea, and hirsutism. Data were obtained from the personal inventories of 50,145 women ages 20-59 years in TOPS, a weight reduction program. The age-adjusted odds ratios of each condition for heavy smokers compared with nonsmokers were 1.59 for natural menopause, 1.49 for induced menopause, 1.35 for infertility, 1.30 for oligomenorrhea among women younger than 40 years, 1.63 for oligomenorrhea among women 40-49 years, and 1.54 for hirsutism (P less than .05 for oligomenorrhea and P less than .001 for all other risks). The odds ratios were not substantially changed after adjustment for obesity, parity, and husband's education level. These results suggest that smoking may affect the ovaries or hormone metabolism, or both, with medical and cosmetic consequences.
本研究旨在检验吸烟与四种可能与性激素改变相关的临床明显病症之间的关联
自然绝经和人工绝经、不孕、月经过少及多毛症。数据取自TOPS（一个减肥项目）中50145名年龄在20至59岁女性的个人清单。与不吸烟者相比，重度吸烟者每种病症的年龄调整比值比分别为：自然绝经1.59、人工绝经1.49、不孕1.35、40岁以下女性月经过少1.30、40至49岁女性月经过少1.63、多毛症1.54（月经过少P<0.05，所有其他风险P<0.001）。在对肥胖、生育次数和丈夫教育水平进行调整后，比值比没有实质性变化。这些结果表明，吸烟可能影响卵巢或激素代谢，或两者皆有影响，从而产生医学和美容方面的后果。
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