Institute of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia.
Department of Experimental Physics, Faculty of Mathematics, Physics and Informatics, Comenius University, Bratislava, Slovakia.
Appl Microbiol Biotechnol. 2019 Jul;103(13):5117-5129. doi: 10.1007/s00253-019-09877-x. Epub 2019 May 15.
Rapidly evolving cold atmospheric pressure plasma (CAPP)-based technology has been actively used not only in bioresearch but also in biotechnology, food safety and processing, agriculture, and medicine. High variability in plasma device configurations and electrode layouts has accelerated non-thermal plasma applications in treatment of various biomaterials and surfaces of all sizes. Mode of cold plasma action is likely associated with synergistic effect of biologically active plasma components, such as UV radiation or reactive species. CAPP has been employed in inactivation of viruses, to combat resistant microorganisms (antibiotic resistant bacteria, spores, biofilms, fungi) and tumors, to degrade toxins, to modify surfaces and their properties, to increase microbial production of compounds, and to facilitate wound healing, blood coagulation, and teeth whitening. The mini-review provides a brief overview of non-thermal plasma sources and recent achievements in biological sciences. We have also included pros and cons of CAPP technologies as well as future directions in biosciences and their respective industrial fields.
快速发展的冷大气压等离子体（CAPP）技术不仅在生物研究中得到了广泛应用，也在生物技术、食品安全与加工、农业和医学领域得到了应用。等离子体设备配置和电极布局的高度可变性加速了非热等离子体在处理各种生物材料和各种尺寸表面方面的应用。冷等离子体的作用模式可能与生物活性等离子体成分（如紫外线辐射或活性物质）的协同效应有关。CAPP 已被用于病毒灭活、抵抗微生物（抗生素耐药细菌、孢子、生物膜、真菌）和肿瘤的治疗、毒素降解、表面及其特性的修饰、增加微生物化合物的生产以及促进伤口愈合、血液凝固和牙齿美白。这篇小型综述简要概述了非热等离子体源和生物学科学的最新成就。我们还包括了 CAPP 技术的优缺点，以及生物科学及其各自的工业领域的未来发展方向。
