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克服抗生素耐药性:非热等离子体与抗生素联合抑制重要病原体。

Overcoming antibiotic resistance: non-thermal plasma and antibiotics combination inhibits important pathogens.

机构信息

Department of Physics and Measurements, University of Chemistry and Technology in Prague, 160 00 Prague, Czech Republic.

Department of Biotechnology, University of Chemistry and Technology in Prague, 160 00 Prague, Czech Republic.

出版信息

Pathog Dis. 2024 Feb 7;82. doi: 10.1093/femspd/ftae007.

Abstract

Antibiotic resistance (ATBR) is increasing every year as the overuse of antibiotics (ATBs) and the lack of newly emerging antimicrobial agents lead to an efficient pathogen escape from ATBs action. This trend is alarming and the World Health Organization warned in 2021 that ATBR could become the leading cause of death worldwide by 2050. The development of novel ATBs is not fast enough considering the situation, and alternative strategies are therefore urgently required. One such alternative may be the use of non-thermal plasma (NTP), a well-established antimicrobial agent actively used in a growing number of medical fields. Despite its efficiency, NTP alone is not always sufficient to completely eliminate pathogens. However, NTP combined with ATBs is more potent and evidence has been emerging over the last few years proving this is a robust and highly effective strategy to fight resistant pathogens. This minireview summarizes experimental research addressing the potential of the NTP-ATBs combination, particularly for inhibiting planktonic and biofilm growth and treating infections in mouse models caused by methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa. The published studies highlight this combination as a promising solution to emerging ATBR, and further research is therefore highly desirable.

摘要

抗生素耐药性(ATBR)每年都在增加,这是由于抗生素(ATBs)的过度使用和新出现的抗菌药物的缺乏,导致病原体有效地逃避了抗生素的作用。这种趋势令人震惊,世界卫生组织在 2021 年警告说,到 2050 年,抗生素耐药性可能成为全球主要的死亡原因。考虑到这种情况,新型抗生素的发展速度还不够快,因此迫切需要替代策略。一种这样的替代方法可能是使用非热等离子体(NTP),这是一种经过充分验证的抗菌剂,在越来越多的医学领域得到积极应用。尽管 NTP 本身的效率很高,但它并不总是足以完全消除病原体。然而,NTP 与抗生素联合使用时更有效,近年来的证据表明,这是一种对抗耐药病原体的强大而高效的策略。这篇迷你评论总结了针对 NTP-抗生素联合使用潜力的实验研究,特别是针对抑制浮游生物和生物膜生长以及治疗耐甲氧西林金黄色葡萄球菌或铜绿假单胞菌引起的小鼠模型感染的研究。已发表的研究强调了这种联合使用是应对新兴抗生素耐药性的有前途的解决方案,因此非常需要进一步的研究。

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