Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from (Mart.) O. Berg (Myrtaceae).

Chemical investigation of the extracts of the fruits from resulted in the isolation of six known compounds identified by NMR and comparison with literature data (2',4'-dihydroxy-5'-methyl-6'-methoxychalcone (), 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone (), 2'-hydroxy-3'-methyl-4',6'-dimethoxychalcone (), 2',6'-dihydroxy-3'-methyl-4'-methoxychalcone (), 5-hydroxy-7-methoxy-8-methylflavanone () and 7-hydroxy-5-methoxy-6-methylflavanone ()). The considerable antioxidant capacity of the extracts was demonstrated by ORAC-FL and DPPH tests. The antiproliferative assay of the extracts and was done , against many different cancer cell lines besides a healthy one. The extracts presented low cytotoxicity and the substance demonstrated promising results against all the cancer cell lines tested, with IC values ranging from 4.75 to 45.81 µmol L. The trypanocidal activity was evaluated against the epimastigote form of the Y strain of and an improvement in the activity of the substances (221.81 µmol L) and (61.87 µmol L) was observed regarding the values obtained for the extracts.