六新甲基阿比呋喃糖苷从树皮 Schneid 和他们的抑制作用对一氧化氮的生产。
Six New Methyl Apiofuranosides from the Bark of Schneid and Their Inhibitory Effects on Nitric Oxide Production.
机构信息
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
出版信息
Molecules. 2019 May 14;24(10):1851. doi: 10.3390/molecules24101851.
A chemical investigation on 70% EtOH extract from the bark of Schneid (Rutaceae) led to six new methyl apiofuranosides (-), and ten known compounds (-). All these compounds were characterized by the basic analysis of the spectroscopic data including extensive 1D-, 2D-NMR (HSQC, HMBC), and high-resolution mass spectrometry, and the absolute configurations were determined by both empirical approaches and NOESY. Inhibitory effects of compounds - and - on nitric oxide production were investigated in lipopolysaccharide (LPS)-mediated RAW 264.7 cells, as a result, most of these isolates inhibited nitric oxide (NO) release, and among them , and displayed the strongest inhibition on NO release at the concentration of 12.5 μM.
对来自 Schneid（芸香科）树皮的 70%EtOH 提取物进行化学研究，分离得到了六个新的甲基阿比呋喃糖苷（-）和十个已知化合物（-）。所有这些化合物均通过包括广泛的 1D-NMR（HSQC、HMBC）和高分辨率质谱在内的光谱数据的基本分析进行了表征，并通过经验方法和 NOESY 确定了绝对构型。对化合物 - 和 - 在脂多糖 (LPS) 介导的 RAW 264.7 细胞中产生一氧化氮 (NO) 的抑制作用进行了研究，结果表明，这些分离物大部分均抑制了一氧化氮 (NO) 的释放，其中，和 对 NO 释放的抑制作用最强，在 12.5 μM 的浓度下。
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