Hedner J, McCown T J, Mueller R A, Hedner T, Jonason J, Breese G R
Acta Physiol Scand. 1987 May;130(1):69-75. doi: 10.1111/j.1748-1716.1987.tb08113.x.
Thyrotropin-releasing hormone (TRH) has previously been found to have a potent respiratory stimulant effect following intracerebroventricular administration. One part of the respiratory response, the shortening of inspiratory time, seems to be elicited from the raphe obscurus in the medulla. The prominent tachypnoea however is not elicited after local injections in the medullary region. In the present paper a micro-injection technique was employed to study respiratory actions of TRH in lightly anaesthetized rats kept in a whole body plethysmograph. Thyrotropin-releasing hormone in a dose of 100 ng per 0.5 microliter was found to induce an immediate tachypnoea after injections into the region of the interpeduncular nucleus of the midbrain. No effects on systemic circulation were seen. More rostral or dorsal sites of injection were without effect. The localization of the sites responsible for respiratory stimulation corresponds to the reticular activating system where electrical stimulation induces hyperventilation in cats. The tachypnoea might be closely related to the well known arousal effects of TRH.
促甲状腺激素释放激素（TRH）此前已被发现，在脑室内给药后具有强大的呼吸刺激作用。呼吸反应的一部分，即吸气时间缩短，似乎是由延髓中缝隐核引发的。然而，在延髓区域进行局部注射后，并未引发明显的呼吸急促。在本文中，采用微量注射技术，研究了TRH对置于全身体积描记器中的轻度麻醉大鼠的呼吸作用。发现以每0.5微升100纳克的剂量向中脑脚间核区域注射促甲状腺激素释放激素后，会立即引发呼吸急促。未观察到对体循环的影响。更靠前或靠上的注射部位则无作用。负责呼吸刺激的部位定位与网状激活系统相对应，在猫中，电刺激该系统会诱发过度通气。呼吸急促可能与TRH广为人知的唤醒作用密切相关。
