Chellappan Dinesh Kumar, Yee Neoh Jia, Kaur Ambar Jeet Singh Bhalqish Jeet, Panneerselvam Jithendra, Madheswaran Thiagarajan, Chellian Jestin, Satija Saurabh, Mehta Meenu, Gulati Monica, Gupta Gaurav, Dua Kamal
Department of Life Sciences, International Medical University, Kuala Lumpur, Malaysia 57000.
School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia 57000.
Ther Deliv. 2019 May 1;10(5):281-293. doi: 10.4155/tde-2019-0019. Epub 2019 May 16.
Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.
我们的目标是研发并表征一种同时含有格列本脲和槲皮素的纳米凝胶制剂，并探究该组合的渗透特性。通过离子凝胶法制备载药纳米凝胶。此外，还获得了格列本脲和槲皮素的最佳包封率。在最佳条件下，用Zetasizer测定纳米颗粒的平均粒径。发现纳米凝胶的粒径为370.4 ± 4.78 nm，多分散指数为0.528 ± 0.04，而ζ电位在17.6至24.8 mV范围内为正值。药物累积释放百分比也显示出良好的结果。壳聚糖纳米凝胶可能是通过皮肤递送格列本脲和槲皮素的一种潜在替代物。
