诺如病毒、宿主和微生物组之间的相互作用。
Interactions between noroviruses, the host, and the microbiota.
机构信息
Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Curr Opin Virol. 2019 Aug;37:1-9. doi: 10.1016/j.coviro.2019.04.001. Epub 2019 May 13.
Abstract
In recent years, appreciation has been growing for the role that the microbiota plays in interactions between the host and various pathogens, including norovirus. Proviral and antiviral effects of the microbiota have been observed for both human and murine noroviruses, and it has become clear that direct effects of microbes and their metabolites as well as indirect effects of commensals on the host are key in modulating pathogenesis. In particular, a common thread has emerged in the ability of members of the microbiota to regulate the host interferon response, thereby modulating norovirus infection. Here, we highlight key differences between human and murine noroviruses and their interactions with the microbiota, while also underscoring shared characteristics between noroviruses and other gastrointestinal viruses.
摘要
近年来，人们越来越认识到微生物组在宿主与包括诺如病毒在内的各种病原体相互作用中所起的作用。人们已经观察到微生物组对人和鼠诺如病毒都有促进病毒和抗病毒的作用，并且很明显，微生物及其代谢物的直接作用以及共生体对宿主的间接作用是调节发病机制的关键。特别是，微生物群成员调节宿主干扰素反应的能力，从而调节诺如病毒感染的能力，这一点已经成为一个共同的线索。在这里，我们重点介绍了人源和鼠源诺如病毒之间的关键差异及其与微生物组的相互作用，同时也强调了诺如病毒与其他胃肠道病毒之间的共同特征。
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