Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Medical Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Epidemiol Health. 2019;41:e2019021. doi: 10.4178/epih.e2019021. Epub 2019 May 17.
Toxoplasmosis is a serious zoonotic disease that can lead to abortion and congenital disorders and has a widespread global distribution in humans and animals. The objective of this review was to investigate the incidence of toxoplasmosis in Iranian neonates in order to obtain a comprehensive assessment of the overall situation of the disease for use in developing future interventions. Original studies investigating the incidence of Toxoplasma gondii infections in Iranian neonates were systematically searched in a number of English-language and Persian-language electronic databases. The search process resulted in the inclusion of a total of 11 studies in the systematic review, 10 of which were entered into the meta-analysis. The reviewed articles included 2,230 Iranian neonates investigated through January 1, 2018. Based on the retrieved studies, the overall weighted incidence rates of toxoplasmosis in the Iranian neonatal population and neonates with suspected congenital toxoplasmosis were estimated to be 0.64% (95% confidence interval [CI], 0.31 to 1.09) and 4.10% (95% CI, 2.68 to 5.77), respectively, using a fixed-effects model. The findings of the reviewed studies demonstrate that the incidence of toxoplasmosis is high in Iranian neonates. Accordingly, it can be concluded that toxoplasmosis is a serious public health concern that has been ignored by the Ministry of Health. Therefore, it is essential to perform further studies, in addition to implementing screening and detection programs, using standardized methods to estimate the incidence of toxoplasmosis in Iran and to determine its associated risk factors.
弓形虫病是一种严重的人畜共患疾病，可导致流产和先天畸形，在人类和动物中广泛分布。本综述的目的是调查伊朗新生儿弓形虫病的发病率，以便全面评估该疾病的总体情况，为未来的干预措施提供依据。系统检索了多个英文和波斯文电子数据库中关于伊朗新生儿弓形虫感染发病率的原始研究。检索过程共纳入了 11 项系统评价研究，其中 10 项纳入了荟萃分析。综述文章纳入了 2230 名于 2018 年 1 月 1 日前接受调查的伊朗新生儿。根据检索到的研究，采用固定效应模型估计伊朗新生儿和疑似先天性弓形虫病新生儿的弓形虫病总加权发病率分别为 0.64%（95%置信区间，0.31%1.09%）和 4.10%（95%置信区间，2.68%5.77%）。综述研究结果表明，伊朗新生儿弓形虫病的发病率较高。因此，可以得出结论，弓形虫病是一个严重的公共卫生问题，而这一问题一直被伊朗卫生部所忽视。因此，有必要进一步开展研究，除了实施筛查和检测计划外，还需要采用标准化方法来评估伊朗的弓形虫病发病率及其相关危险因素。
