下一代基因组注释：我们仍在努力做到正确。
Next-generation genome annotation: we still struggle to get it right.
机构信息
Departments of Biomedical Engineering, Computer Science, and Biostatistics, Johns Hopkins University, Baltimore, MD, 21205, USA.
出版信息
Genome Biol. 2019 May 16;20(1):92. doi: 10.1186/s13059-019-1715-2.
Abstract
While the genome sequencing revolution has led to the sequencing and assembly of many thousands of new genomes, genome annotation still uses very nearly the same technology that we have used for the past two decades. The sheer number of genomes necessitates the use of fully automated procedures for annotation, but errors in annotation are just as prevalent as they were in the past, if not more so. How are we to solve this growing problem?
摘要
虽然基因组测序革命已经导致了数千个新基因组的测序和组装，但基因组注释仍然使用的是我们过去二十年来使用的几乎相同的技术。注释所需的基因组数量如此之多，以至于必须使用完全自动化的注释程序，但注释错误的普遍程度与过去一样，如果不是更严重的话。我们如何解决这个日益严重的问题？
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