Mustafa Madinna, Fathy Fatima, Mirghani Abubaker, Mohamed Mona A, Muneer Mohamed S, Ahmed Abdallah E, Ali Mohamed Siralkhatim, Omer Rihab A, Siddig Emmanuel E, Mohamed Nouh S, Abd Elkareem Amjed M
Department of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, Nile College, Khartoum, Sudan.
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
BMC Res Notes. 2019 May 16;12(1):279. doi: 10.1186/s13104-019-4314-0.
Toxoplasma gondii is an opportunistic parasite that causes a clinical manifestation known as toxoplasmosis. We investigated the prevalence and potential risk factors of T. gondii infection among women in Khartoum, Sudan. A sero-parasitological cross-sectional study included 100 women aging between 15 and 50 years old was conducted between January and November 2018. Serum samples were collected and investigated for the presence of anti-T. gondii immunoglobulins.
Mean age of the women population included was 26.75 ± 8.25 with a range between 15 and 50 years. Sero-prevalence of T. gondii antibodies was 27% (27/100) with a 95% confidence interval (CI) of 18.6-36.8%. Among seropositive population 81% (22/27), 15% (4/27) and 4% (1/27) were seropositive for IgG antibodies, IgM antibodies and both antibodies respectively. Age group 21-30 years old had the highest frequency of detected IgG (10/45) and IgM (3/45). Married women had the highest frequency of detected IgG or IgM, 18/79 and 3/79, respectively. Risk factors analysis showed a total of 37/100 participants were having direct contact with cats and 66/100 have a frequent raw meat consumption, neither direct cats contact nor raw meat consumption had a statistically significant association with seropositivity to T. gondii (P value = 0.052 and 0.565, respectively).
刚地弓形虫是一种机会性寄生虫，可引发一种名为弓形虫病的临床表现。我们调查了苏丹喀土穆女性中刚地弓形虫感染的患病率及潜在风险因素。2018年1月至11月间开展了一项血清学-寄生虫学横断面研究，纳入了100名年龄在15至50岁之间的女性。采集血清样本并检测抗刚地弓形虫免疫球蛋白的存在情况。
纳入的女性人群平均年龄为26.75±8.25岁，年龄范围在15至50岁之间。刚地弓形虫抗体的血清学患病率为27%（27/100），95%置信区间（CI）为18.6 - 36.8%。在血清阳性人群中，IgG抗体、IgM抗体及两种抗体均呈血清阳性的比例分别为81%（22/27）、15%（4/27）和4%（1/27）。21至30岁年龄组检测到的IgG（10/45）和IgM（3/45）频率最高。已婚女性检测到IgG或IgM的频率最高，分别为18/79和3/79。风险因素分析显示，共有37/100的参与者与猫有直接接触，66/100的参与者经常食用生肉，与刚地弓形虫血清阳性均无统计学显著关联（P值分别为0.052和0.565）。
