Cong Wei, Dong Xiao-Yan, Meng Qing-Feng, Zhou Na, Wang Xiang-Yang, Huang Si-Yang, Zhu Xing-Quan, Qian Ai-Dong
College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, China ; State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
Wendeng Stomatology Hospital, Weihai, Shandong 264200, China.
Biomed Res Int. 2015;2015:170278. doi: 10.1155/2015/170278. Epub 2015 Oct 11.
Very limited information is available concerning the epidemiology of T. gondii infection in pregnant women in eastern China. Therefore, a case-control study was conducted to estimate the seroprevalence of toxoplasmosis in this population group and to identify risk factors and possible routes of contamination. Serum samples were collected from 965 pregnant women and 965 age-matched nonpregnant control subjects in Qingdao and Weihai between October 2011 and July 2013. These were screened with enzyme linked immunoassays for the presence of anti-Toxoplasma IgG and anti-Toxoplasma IgM antibodies. 147 (15.2%) pregnant women and 167 (17.3%) control subjects were positive for anti-T. gondii IgG antibodies, while 28 (2.9%) pregnant women and 37 (3.8%) controls were positive for anti-T. gondii IgM antibodies (P = 0.256). There was no significant difference between pregnant women and nonpregnant controls with regard to the seroprevalence of either anti-T. gondii IgG or IgM antibodies. Multivariate analysis showed that T. gondii infection was associated with location, cats in home, contact with cats and dogs, and exposure to soil. The results indicated that the seroprevalence of T. gondii infection in pregnant women is high compared to most other regions of China and other East Asian countries with similar climatic conditions.
关于中国东部孕妇弓形虫感染的流行病学信息非常有限。因此，开展了一项病例对照研究，以估计该人群弓形虫病的血清阳性率，并确定危险因素和可能的污染途径。2011年10月至2013年7月期间，从青岛和威海的965名孕妇和965名年龄匹配的非孕妇对照受试者中采集血清样本。用酶联免疫吸附测定法检测抗弓形虫IgG和抗弓形虫IgM抗体的存在。147名（15.2%）孕妇和167名（17.3%）对照受试者抗弓形虫IgG抗体呈阳性，而28名（2.9%）孕妇和37名（3.8%）对照受试者抗弓形虫IgM抗体呈阳性（P = 0.256）。孕妇和非孕妇对照在抗弓形虫IgG或IgM抗体的血清阳性率方面没有显著差异。多变量分析表明，弓形虫感染与地点、家中养猫、与猫和狗接触以及接触土壤有关。结果表明，与中国其他大多数地区以及气候条件相似的其他东亚国家相比，孕妇弓形虫感染的血清阳性率较高。
