Takafuji Madoka, Tanemura Atsushi, Katayama Ichiro
Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan.
Case Rep Dermatol. 2019 Mar 28;11(1):86-90. doi: 10.1159/000499031. eCollection 2019 Jan-Apr.
We report the case of a 73-year-old woman with leukoderma induced by cosmetics containing ascorbic acid. She had noticed the sudden appearance of a hypopigmented macule on the cheek within 1 month after use of the cosmetics with the brand name Obaji C Serum. No history of use of rhododenol-containing cosmetics was declared. Histopathological analysis revealed that the number of matured melanocytes was apparently decreased, and T lymphocytes abundantly infiltrated mainly the perifollicular region. In addition to the discontinuation of using Obaji C Serum, phototherapy by excimer light was noticeably effective for repigmentation. To our knowledge, there has been no other report so far showing hypopigmented lesions induced by this cosmetic.
我们报告了一例73岁女性因使用含抗坏血酸的化妆品而诱发白斑病的病例。她在使用名为Obaji C精华液的化妆品后1个月内，注意到脸颊上突然出现了一个色素减退斑。她并未声明有使用含杜鹃醇化妆品的历史。组织病理学分析显示，成熟黑素细胞数量明显减少，T淋巴细胞大量浸润，主要位于毛囊周围区域。除停用Obaji C精华液外，准分子光光疗对色素沉着恢复有显著效果。据我们所知，目前尚无其他报告显示该化妆品会诱发色素减退性病变。
