Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Chemosphere. 2019 Nov;235:713-718. doi: 10.1016/j.chemosphere.2019.06.185. Epub 2019 Jun 26.
Chemical leukoderma is a patchy hypopigmentation in the skin. Phenol derivatives such as raspberry ketone have been reported to cause the development of occupationally induced leukoderma. Recently, 2% (w/w) rhododenol, a reduced form of raspberry ketone used in a skin-lightning agent, also caused the development of leukoderma in >16,000 users, about 2% of all users, in Asian countries including Japan. However, a method for assessing the risk of leukoderma caused by 2% rhododenol has not been established despite the fact that the development of leukoderma caused by 30% rhododenol was previously shown in animal experiments. Establishment of a novel technique for risk assessment of leukoderma in humans caused by external treatment with chemicals is needed to prevent a possible future chemical disaster. This study demonstrated that external treatment with 2% rhododenol and the same concentration of raspberry ketone caused the development of leukoderma in murine tail skin without exception with significant decreases in the amount of melanin and number of melanocytes in the epidermis. Thus, a novel in vivo technique that can assess the risk of leukoderma caused by 2% rhododenol was developed. The unique technique using tail skin has the potential to prevent chemical leukoderma in the future.
化学性白斑是皮肤的一种斑片状色素减退。据报道，苯乙酮等酚类衍生物会导致职业性白斑的发生。最近，2%（w/w）的岩蔷薇醇（一种用于皮肤增亮剂的苯乙酮还原形式）也导致包括日本在内的亚洲国家超过 16000 名使用者（约占所有使用者的 2%）出现了白斑。然而，尽管之前的动物实验表明 30%岩蔷薇醇会导致白斑的发展，但尚未建立评估 2%岩蔷薇醇引起白斑风险的方法。建立一种用于评估人类因外部化学处理引起的白斑风险的新技术，以防止可能发生的未来化学灾难，是必要的。本研究表明，2%岩蔷薇醇和相同浓度的苯乙酮的外部处理无一例外地导致了小鼠尾巴皮肤的白斑形成，表皮中的黑色素含量和黑素细胞数量显著减少。因此，开发了一种可以评估 2%岩蔷薇醇引起的白斑风险的新的体内技术。这种使用尾巴皮肤的独特技术有可能在未来预防化学性白斑。
