Diacetal Ditellurides as Highly Active and Selective Antiparasitic Agents toward .

Leishmaniasis is a neglected tropical disease and a public health concern in at least 98 countries, affecting mainly the poorest populations. Pharmaceuticals and chemotherapies available for leishmaniasis treatment have several limitations, which clearly justify the efforts to find new potential antileishmanial drugs. In this context, antiprotozoal activities toward different species have been reported for hypervalent tellurium compounds, which motivated us to investigate, for the first time, the leishmanicidal properties of some nonhypervalent diaryl ditellurides. Thus, this work describes activity against and the cytotoxicities of diaryl ditellurides. Ditelluride revealed a strong leishmanicidal activity on promastigotes and amastigotes at submicromolar levels (IC = 0.9 ± 0.1 and 0.5 ± 0.1 μmol L, respectively) and presented selectivity indexes greater than those of reference drug miltefosine. This preliminary study suggests that diaryl ditellurides may be promising scaffolds for the development of new agents for leishmaniasis treatment.