Department of Zoology, Faculty of Science, Damanhūr University, Damanhūr, 22511, Egypt.
Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Via San Donato 15, 40127, Bologna, Italy.
Geroscience. 2020 Jun;42(3):867-879. doi: 10.1007/s11357-019-00066-2. Epub 2019 May 16.
Cellular senescence is a fundamental process that may play positive or detrimental roles for the organism. It is involved in tissue development and in tumor prevention although during aging is becoming a detrimental process contributing to the decline of tissue functions. In previous investigations, we have uncovered a better capacity to detect DNA damage in cells from long-lived mammals. Here, we report that cultured cells derived from long-lived species have a higher propensity to undergo senescence when challenged with DNA damage than cells derived from short-lived species. Using a panel of cells derived from six mammals, which range in lifespan from 3-4 years up to 120 years, we examined cell cycle response, induction of apoptosis and of cellular senescence. All species exhibited a cell cycle arrest while induction of apoptosis was variable. However, a significant positive correlation was found between the relative percent of cells, within a population which entered senescence following damage, and the lifespan of the species. We suggest that cellular senescence may have a positive role during development allowing it to contribute to the evolution of longevity.
细胞衰老（Cellular senescence）是一种可能对生物体产生积极或消极影响的基本过程。它参与组织发育和肿瘤预防，尽管在衰老过程中，它会成为导致组织功能下降的有害过程。在之前的研究中，我们发现，长寿哺乳动物的细胞具有更好的检测 DNA 损伤的能力。在这里，我们报告称，与来自短寿物种的细胞相比，来自长寿物种的培养细胞在受到 DNA 损伤时更容易发生衰老。我们使用一组源自六种哺乳动物的细胞进行研究，这些哺乳动物的寿命从 3-4 年到 120 年不等，我们检测了细胞周期反应、细胞凋亡和细胞衰老的诱导。所有物种在诱导细胞凋亡方面存在差异，但在细胞周期阻滞方面表现一致。然而，我们发现，在受到损伤后进入衰老的细胞群体中，细胞衰老的相对百分比与物种的寿命之间存在显著的正相关关系。我们认为，细胞衰老在发育过程中可能具有积极作用，有助于长寿的进化。
