Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Department of Geriatrics, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Neurodegener Dis. 2018;18(5-6):270-280. doi: 10.1159/000495754. Epub 2019 Jan 23.
(1) To investigate atrophy patterns of hippocampal subfield volume and Alzheimer's disease (AD)-signature cortical thickness in mild cognitive impairment (MCI) patients; (2) to explore the association between the neuropsychological (NP) and the brain structure in the MCI and older normal cognition group; (3) to determine whether these associations were modified by the apolipoprotein E (APOE) ε4 gene and cognitive status.
The FreeSurfer software was used for automated segmentation of hippocampal subfields and AD-signature cortical thickness for 22 MCI patients and 23 cognitive normal controls (NC). The volume, cortical thickness, and the neuropsychological scale were compared with two-sample t tests. Linear regression models were used to determine the association between the NP and the brain structure.
Compared with the NC group, MCI patients showed a decreased volume of the left presubiculum, subiculum and right CA2_3 and CA4_DG (p < 0.05, FDR corrected). The volume of these regions was positively correlated with NP scores. Of note, these associations depended on the cognitive status but not on the APOE ε4 status. The left subiculum and presubiculum volume were positively correlated with the Montreal Cognitive Assessment (MoCA) scores only in the MCI patients.
Atrophy of the hippocampal subfields may be a powerful biomarker for MCI in the Chinese population.
(1) 研究轻度认知障碍 (MCI) 患者海马亚区体积和阿尔茨海默病 (AD) 特征性皮质厚度的萎缩模式；(2) 探讨 MCI 和老年认知正常组中神经心理学 (NP) 和大脑结构之间的关系；(3) 确定这些关联是否受载脂蛋白 E (APOE) ε4 基因和认知状态的影响。
使用 FreeSurfer 软件对 22 名 MCI 患者和 23 名认知正常对照组 (NC) 的海马亚区和 AD 特征性皮质厚度进行自动分割。采用两样本 t 检验比较体积、皮质厚度和神经心理学量表。采用线性回归模型确定 NP 与大脑结构之间的关系。
与 NC 组相比，MCI 患者左前下托、下托和右 CA2_3 和 CA4_DG 的体积减小 (p < 0.05，经 FDR 校正)。这些区域的体积与 NP 评分呈正相关。值得注意的是，这些关联取决于认知状态，而与 APOE ε4 状态无关。左海马旁回和前下托体积仅与 MCI 患者的蒙特利尔认知评估 (MoCA) 评分呈正相关。
海马亚区的萎缩可能是中国人 MCI 的一个强有力的生物标志物。
